Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5610
Gene Symbol: EIF2AK2
EIF2AK2
0.330 Biomarker disease BEFREE As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells. 11719449 2001
Entrez Id: 5610
Gene Symbol: EIF2AK2
EIF2AK2
0.330 Biomarker disease BEFREE Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response. 10846107 2000
Entrez Id: 5610
Gene Symbol: EIF2AK2
EIF2AK2
0.330 Biomarker disease CTD_human A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2. 23326326 2013
Entrez Id: 5610
Gene Symbol: EIF2AK2
EIF2AK2
0.330 Biomarker disease BEFREE Unlike other viral proteins, such as influenza virus NS1, the leader protein appears to interact with neither PKR nor double-stranded RNA, suggesting that it acts indirectly to trigger the inhibition of the kinase. 31292248 2019