Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE We studied the safety and immunogenicity of an influenza strain lacking the NS1 gene (DeltaNS1-H1N1) in healthy volunteers.METHODS. 20039806 2010
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE We propose that NS1 protein of both H5N1 and H11N1 subtypes of influenza viruses are capable of influencing host immune responses and possess necessary functionality to support apoptosis in host cells. 22866982 2012
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE We designed six primers targeting the matrix genes of influenza H1 and H3 and the NS1 gene of influenza B and developed a M-LAMP assay using a commercially available Master Mix and a real time fluorometer (Genie II, Optigene, UK) that displays real time amplification, time to positivity and amplicon annealing temperature (Tm). 23827787 2013
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Viral proteins such as the NS1 protein of Influenza virus A act upstream of the pathway while other viral proteins such as Theiler's virus L* protein act downstream. 26231767 2015
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Unlike other influenza viruses, engineering truncations hypothesized to reduce interferon antagonism into the NS1 protein didn't attenuate bat-influenza. 25275541 2014
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE To this end, we compared autophagy in cells infected with wild-type (WT) influenza virus and virus lacking the NS1 gene (delNS1 virus). 24027311 2013
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation. 21163951 2011
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Thus, DP<sub>92-93</sub> in the NS1 protein may confer a disadvantage to Influenza B viruses circulating in the human population and interestingly the low frequency of DP<sub>92-93</sub>detection in the NS1 protein since 2004 is consistent with this suggestion. 28348873 2016
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE This study aims at improving our understanding on the pathogenic mechanism of influenza viruses, in particular the role of non-structural (NS1) protein in inducing pro-inflammatory and apoptotic responses. 22185562 2011
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. 30177761 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE These findings suggest that the NS1 protein plays a role in the regulation of splicing of influenza virus M1 mRNA. 21918006 2012
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The results of this study improve our understanding of C-terminal region function for NS1 proteins of influenza viruses. 30322535 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The fact that influenza A and influenza B virus NS1 proteins bind to NS1-I suggests that this cellular protein plays a role in the influenza virus life cycle. 8764047 1996
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The C-terminal tail of influenza virus NS1 protein constitutes a nucleolar localization signal (NoLS) and is the binding domain of the cellular pre-mRNA processing protein, poly(A)-binding protein II (PABII). 22022552 2011
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The NS1 protein of influenza virus is a virulence element and the critical factor for regulation of the host immune response during virus infection. 31530680 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The NS1 protein of influenza viruses is a major virulence factor and exerts its function through interacting with viral/cellular RNAs and proteins. 24418537 2014
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains present in multiple host proteins, whereas no such motif is found in the NS1 homologues of seasonal human virus strains. 20686040 2010
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways. 19706713 2009
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I. 31843969 2020
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 AlteredExpression disease BEFREE The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs. 30538201 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The influenza virus NS1 protein as a therapeutic target. 23796981 2013
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Roles of its virulence factor, NS1 protein in influenza virus infected neuron has yet to be explored. 28992616 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Our studies revealed an extensive diversity of influenza virus-specific CD4 T cells that includes T cells for each viral protein and for the unexpected immunogenicity of the NS1 protein. 19386707 2009
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response. 10846107 2000
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection. 28003482 2017