IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the safety and immunogenicity of an influenza strain lacking the NS1 gene (DeltaNS1-H1N1) in healthy volunteers.METHODS.
|
20039806 |
2010 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose that NS1 protein of both H5N1 and H11N1 subtypes of influenza viruses are capable of influencing host immune responses and possess necessary functionality to support apoptosis in host cells.
|
22866982 |
2012 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
We designed six primers targeting the matrix genes of influenza H1 and H3 and the NS1 gene of influenza B and developed a M-LAMP assay using a commercially available Master Mix and a real time fluorometer (Genie II, Optigene, UK) that displays real time amplification, time to positivity and amplicon annealing temperature (Tm).
|
23827787 |
2013 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Viral proteins such as the NS1 protein of Influenza virus A act upstream of the pathway while other viral proteins such as Theiler's virus L* protein act downstream.
|
26231767 |
2015 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unlike other influenza viruses, engineering truncations hypothesized to reduce interferon antagonism into the NS1 protein didn't attenuate bat-influenza.
|
25275541 |
2014 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
To this end, we compared autophagy in cells infected with wild-type (WT) influenza virus and virus lacking the NS1 gene (delNS1 virus).
|
24027311 |
2013 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation.
|
21163951 |
2011 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, DP<sub>92-93</sub> in the NS1 protein may confer a disadvantage to Influenza B viruses circulating in the human population and interestingly the low frequency of DP<sub>92-93</sub>detection in the NS1 protein since 2004 is consistent with this suggestion.
|
28348873 |
2016 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aims at improving our understanding on the pathogenic mechanism of influenza viruses, in particular the role of non-structural (NS1) protein in inducing pro-inflammatory and apoptotic responses.
|
22185562 |
2011 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain.
|
30177761 |
2018 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the NS1 protein plays a role in the regulation of splicing of influenza virus M1 mRNA.
|
21918006 |
2012 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of this study improve our understanding of C-terminal region function for NS1 proteins of influenza viruses.
|
30322535 |
2018 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The fact that influenza A and influenza B virus NS1 proteins bind to NS1-I suggests that this cellular protein plays a role in the influenza virus life cycle.
|
8764047 |
1996 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The C-terminal tail of influenza virus NS1 protein constitutes a nucleolar localization signal (NoLS) and is the binding domain of the cellular pre-mRNA processing protein, poly(A)-binding protein II (PABII).
|
22022552 |
2011 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 protein of influenza virus is a virulence element and the critical factor for regulation of the host immune response during virus infection.
|
31530680 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 protein of influenza viruses is a major virulence factor and exerts its function through interacting with viral/cellular RNAs and proteins.
|
24418537 |
2014 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains present in multiple host proteins, whereas no such motif is found in the NS1 homologues of seasonal human virus strains.
|
20686040 |
2010 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways.
|
19706713 |
2009 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.
|
31843969 |
2020 |
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs.
|
30538201 |
2018 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influenza virus NS1 protein as a therapeutic target.
|
23796981 |
2013 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Roles of its virulence factor, NS1 protein in influenza virus infected neuron has yet to be explored.
|
28992616 |
2017 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our studies revealed an extensive diversity of influenza virus-specific CD4 T cells that includes T cells for each viral protein and for the unexpected immunogenicity of the NS1 protein.
|
19386707 |
2009 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response.
|
10846107 |
2000 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection.
|
28003482 |
2017 |