|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 protein of influenza viruses is a major virulence factor and exerts its function through interacting with viral/cellular RNAs and proteins.
|
24418537 |
2014 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The fact that influenza A and influenza B virus NS1 proteins bind to NS1-I suggests that this cellular protein plays a role in the influenza virus life cycle.
|
8764047 |
1996 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection.
|
28003482 |
2017 |
|
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Human interactome of the influenza B virus NS1 protein.
|
28869005 |
2017 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influenza virus surveillance to identify new mutations in the NS1 protein affecting innate immune responses and, as a consequence, the pathogenicity of the circulating viruses is highly relevant.
|
27535054 |
2016 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
To this end, we compared autophagy in cells infected with wild-type (WT) influenza virus and virus lacking the NS1 gene (delNS1 virus).
|
24027311 |
2013 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The C-terminal tail of influenza virus NS1 protein constitutes a nucleolar localization signal (NoLS) and is the binding domain of the cellular pre-mRNA processing protein, poly(A)-binding protein II (PABII).
|
22022552 |
2011 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.
|
31843969 |
2020 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the safety and immunogenicity of an influenza strain lacking the NS1 gene (DeltaNS1-H1N1) in healthy volunteers.METHODS.
|
20039806 |
2010 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation.
|
21163951 |
2011 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influenza virus NS1 protein as a therapeutic target.
|
23796981 |
2013 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis.
|
31104825 |
2019 |
|
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the present results indicate that the influenza B virus NS1 protein (NS1-B) is unable to interact with RIG-I but engages in the formation of a RIG-I/TRIM25/NS1-B ternary complex.
|
27122586 |
2016 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Large-scale sequence analyses of influenza viruses revealed that nonstructural 1 (NS1) proteins from avian influenza viruses have a conserved C-terminal ESEV amino acid motif, while NS1 proteins from typical human influenza viruses have a C-terminal RSKV motif.
|
20410267 |
2010 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
In sum, our study uncovers the molecular basis of a major nuclear function of influenza NS1 protein that causes potent blockage of host gene expression and contributes to inhibition of host immunity.
|
31263181 |
2019 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the NS1 protein plays a role in the regulation of splicing of influenza virus M1 mRNA.
|
21918006 |
2012 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose that NS1 protein of both H5N1 and H11N1 subtypes of influenza viruses are capable of influencing host immune responses and possess necessary functionality to support apoptosis in host cells.
|
22866982 |
2012 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAR1 editing activity was enhanced by both viruses through dengue virus NS3 and influenza virus NS1 proteins, suggesting a similar virus-host co-evolution.
|
23853584 |
2013 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
We designed six primers targeting the matrix genes of influenza H1 and H3 and the NS1 gene of influenza B and developed a M-LAMP assay using a commercially available Master Mix and a real time fluorometer (Genie II, Optigene, UK) that displays real time amplification, time to positivity and amplicon annealing temperature (Tm).
|
23827787 |
2013 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aims at improving our understanding on the pathogenic mechanism of influenza viruses, in particular the role of non-structural (NS1) protein in inducing pro-inflammatory and apoptotic responses.
|
22185562 |
2011 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Viral proteins such as the NS1 protein of Influenza virus A act upstream of the pathway while other viral proteins such as Theiler's virus L* protein act downstream.
|
26231767 |
2015 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.
|
28757142 |
2017 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the NS1 protein is known to play a role in immune modulation, no differences were detected in the limited innate immune response to LPAI virus infection.
|
31683727 |
2019 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of this study improve our understanding of C-terminal region function for NS1 proteins of influenza viruses.
|
30322535 |
2018 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 protein of influenza virus is a virulence element and the critical factor for regulation of the host immune response during virus infection.
|
31530680 |
2019 |