IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection.
|
28003482 |
2017 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influenza virus surveillance to identify new mutations in the NS1 protein affecting innate immune responses and, as a consequence, the pathogenicity of the circulating viruses is highly relevant.
|
27535054 |
2016 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.
|
28757142 |
2017 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain.
|
30177761 |
2018 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells.
|
11719449 |
2001 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines.
|
27750071 |
2017 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 protein of influenza viruses is a major virulence factor and exerts its function through interacting with viral/cellular RNAs and proteins.
|
24418537 |
2014 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The fact that influenza A and influenza B virus NS1 proteins bind to NS1-I suggests that this cellular protein plays a role in the influenza virus life cycle.
|
8764047 |
1996 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
To this end, we compared autophagy in cells infected with wild-type (WT) influenza virus and virus lacking the NS1 gene (delNS1 virus).
|
24027311 |
2013 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The C-terminal tail of influenza virus NS1 protein constitutes a nucleolar localization signal (NoLS) and is the binding domain of the cellular pre-mRNA processing protein, poly(A)-binding protein II (PABII).
|
22022552 |
2011 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.
|
31843969 |
2020 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the safety and immunogenicity of an influenza strain lacking the NS1 gene (DeltaNS1-H1N1) in healthy volunteers.METHODS.
|
20039806 |
2010 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation.
|
21163951 |
2011 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influenza virus NS1 protein as a therapeutic target.
|
23796981 |
2013 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis.
|
31104825 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Large-scale sequence analyses of influenza viruses revealed that nonstructural 1 (NS1) proteins from avian influenza viruses have a conserved C-terminal ESEV amino acid motif, while NS1 proteins from typical human influenza viruses have a C-terminal RSKV motif.
|
20410267 |
2010 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
In sum, our study uncovers the molecular basis of a major nuclear function of influenza NS1 protein that causes potent blockage of host gene expression and contributes to inhibition of host immunity.
|
31263181 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the NS1 protein plays a role in the regulation of splicing of influenza virus M1 mRNA.
|
21918006 |
2012 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose that NS1 protein of both H5N1 and H11N1 subtypes of influenza viruses are capable of influencing host immune responses and possess necessary functionality to support apoptosis in host cells.
|
22866982 |
2012 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAR1 editing activity was enhanced by both viruses through dengue virus NS3 and influenza virus NS1 proteins, suggesting a similar virus-host co-evolution.
|
23853584 |
2013 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
We designed six primers targeting the matrix genes of influenza H1 and H3 and the NS1 gene of influenza B and developed a M-LAMP assay using a commercially available Master Mix and a real time fluorometer (Genie II, Optigene, UK) that displays real time amplification, time to positivity and amplicon annealing temperature (Tm).
|
23827787 |
2013 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aims at improving our understanding on the pathogenic mechanism of influenza viruses, in particular the role of non-structural (NS1) protein in inducing pro-inflammatory and apoptotic responses.
|
22185562 |
2011 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Viral proteins such as the NS1 protein of Influenza virus A act upstream of the pathway while other viral proteins such as Theiler's virus L* protein act downstream.
|
26231767 |
2015 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the NS1 protein is known to play a role in immune modulation, no differences were detected in the limited innate immune response to LPAI virus infection.
|
31683727 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of this study improve our understanding of C-terminal region function for NS1 proteins of influenza viruses.
|
30322535 |
2018 |