IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.
|
31843969 |
2020 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis.
|
31104825 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
In sum, our study uncovers the molecular basis of a major nuclear function of influenza NS1 protein that causes potent blockage of host gene expression and contributes to inhibition of host immunity.
|
31263181 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the NS1 protein is known to play a role in immune modulation, no differences were detected in the limited innate immune response to LPAI virus infection.
|
31683727 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 protein of influenza virus is a virulence element and the critical factor for regulation of the host immune response during virus infection.
|
31530680 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation.
|
31470040 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of this study improve our understanding of C-terminal region function for NS1 proteins of influenza viruses.
|
30322535 |
2018 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain.
|
30177761 |
2018 |
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.
|
29921878 |
2018 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site.
|
30024831 |
2018 |
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs.
|
30538201 |
2018 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection.
|
28003482 |
2017 |
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Human interactome of the influenza B virus NS1 protein.
|
28869005 |
2017 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.
|
28757142 |
2017 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lactobacillus casei carrying the NS1 protein could be developed into a universal oral influenza vaccine since the NS1 is highly conserved among influenza viruses.
|
28370088 |
2017 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines.
|
27750071 |
2017 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Roles of its virulence factor, NS1 protein in influenza virus infected neuron has yet to be explored.
|
28992616 |
2017 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influenza virus surveillance to identify new mutations in the NS1 protein affecting innate immune responses and, as a consequence, the pathogenicity of the circulating viruses is highly relevant.
|
27535054 |
2016 |
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the present results indicate that the influenza B virus NS1 protein (NS1-B) is unable to interact with RIG-I but engages in the formation of a RIG-I/TRIM25/NS1-B ternary complex.
|
27122586 |
2016 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Live attenuated influenza vaccine with trunctated NS1 protein as a potential strategy will be extremely useful for improving immune efficacy.
|
26638027 |
2016 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, DP<sub>92-93</sub> in the NS1 protein may confer a disadvantage to Influenza B viruses circulating in the human population and interestingly the low frequency of DP<sub>92-93</sub>detection in the NS1 protein since 2004 is consistent with this suggestion.
|
28348873 |
2016 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Viral proteins such as the NS1 protein of Influenza virus A act upstream of the pathway while other viral proteins such as Theiler's virus L* protein act downstream.
|
26231767 |
2015 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nonstructural protein 1 (NS1) proteins from avian influenza viruses like the 1918 pandemic NS1 are capable of inhibiting the key signaling integrator c-Abl (Abl1), resulting in massive cytopathic cell alterations.
|
25367299 |
2015 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 protein of influenza viruses is a major virulence factor and exerts its function through interacting with viral/cellular RNAs and proteins.
|
24418537 |
2014 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unlike other influenza viruses, engineering truncations hypothesized to reduce interferon antagonism into the NS1 protein didn't attenuate bat-influenza.
|
25275541 |
2014 |