Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I. 31843969 2020
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis. 31104825 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE In sum, our study uncovers the molecular basis of a major nuclear function of influenza NS1 protein that causes potent blockage of host gene expression and contributes to inhibition of host immunity. 31263181 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Although the NS1 protein is known to play a role in immune modulation, no differences were detected in the limited innate immune response to LPAI virus infection. 31683727 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The NS1 protein of influenza virus is a virulence element and the critical factor for regulation of the host immune response during virus infection. 31530680 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation. 31470040 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The results of this study improve our understanding of C-terminal region function for NS1 proteins of influenza viruses. 30322535 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. 30177761 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 AlteredExpression disease BEFREE Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing. 29921878 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site. 30024831 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 AlteredExpression disease BEFREE The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs. 30538201 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection. 28003482 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 AlteredExpression disease BEFREE Human interactome of the influenza B virus NS1 protein. 28869005 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells. 28757142 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Lactobacillus casei carrying the NS1 protein could be developed into a universal oral influenza vaccine since the NS1 is highly conserved among influenza viruses. 28370088 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines. 27750071 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Roles of its virulence factor, NS1 protein in influenza virus infected neuron has yet to be explored. 28992616 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE Influenza virus surveillance to identify new mutations in the NS1 protein affecting innate immune responses and, as a consequence, the pathogenicity of the circulating viruses is highly relevant. 27535054 2016
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 AlteredExpression disease BEFREE However, the present results indicate that the influenza B virus NS1 protein (NS1-B) is unable to interact with RIG-I but engages in the formation of a RIG-I/TRIM25/NS1-B ternary complex. 27122586 2016
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Live attenuated influenza vaccine with trunctated NS1 protein as a potential strategy will be extremely useful for improving immune efficacy. 26638027 2016
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Thus, DP<sub>92-93</sub> in the NS1 protein may confer a disadvantage to Influenza B viruses circulating in the human population and interestingly the low frequency of DP<sub>92-93</sub>detection in the NS1 protein since 2004 is consistent with this suggestion. 28348873 2016
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Viral proteins such as the NS1 protein of Influenza virus A act upstream of the pathway while other viral proteins such as Theiler's virus L* protein act downstream. 26231767 2015
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Nonstructural protein 1 (NS1) proteins from avian influenza viruses like the 1918 pandemic NS1 are capable of inhibiting the key signaling integrator c-Abl (Abl1), resulting in massive cytopathic cell alterations. 25367299 2015
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE The NS1 protein of influenza viruses is a major virulence factor and exerts its function through interacting with viral/cellular RNAs and proteins. 24418537 2014
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Unlike other influenza viruses, engineering truncations hypothesized to reduce interferon antagonism into the NS1 protein didn't attenuate bat-influenza. 25275541 2014