IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model.
|
16545418 |
2006 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza viruses lacking the interferon (IFN)-antagonistic non-structural NS1 protein are strongly attenuated.
|
19726611 |
2009 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influenza virus surveillance to identify new mutations in the NS1 protein affecting innate immune responses and, as a consequence, the pathogenicity of the circulating viruses is highly relevant.
|
27535054 |
2016 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.
|
28757142 |
2017 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis.
|
31104825 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
NS1 protein of influenza virus is a virulence factor that counteracts Type I interferon (IFN)-mediated antiviral response by the host.
|
15054864 |
2004 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAR1 editing activity was enhanced by both viruses through dengue virus NS3 and influenza virus NS1 proteins, suggesting a similar virus-host co-evolution.
|
23853584 |
2013 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the NS1 protein is known to play a role in immune modulation, no differences were detected in the limited innate immune response to LPAI virus infection.
|
31683727 |
2019 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells.
|
11719449 |
2001 |
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines.
|
27750071 |
2017 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza.
|
12149435 |
2002 |
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.
|
29921878 |
2018 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we provide one explanation for this restriction: the species specificity exhibited by the NS1 protein of influenza B virus (NS1B protein).
|
20093371 |
2010 |
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein.
|
22174864 |
2011 |
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the present results indicate that the influenza B virus NS1 protein (NS1-B) is unable to interact with RIG-I but engages in the formation of a RIG-I/TRIM25/NS1-B ternary complex.
|
27122586 |
2016 |
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Human interactome of the influenza B virus NS1 protein.
|
28869005 |
2017 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human monoclonal ScFv specific to NS1 protein inhibits replication of influenza viruses across types and subtypes.
|
23928258 |
2013 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation.
|
31470040 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results indicate that influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production.
|
23209422 |
2012 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
In sum, our study uncovers the molecular basis of a major nuclear function of influenza NS1 protein that causes potent blockage of host gene expression and contributes to inhibition of host immunity.
|
31263181 |
2019 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lactobacillus casei carrying the NS1 protein could be developed into a universal oral influenza vaccine since the NS1 is highly conserved among influenza viruses.
|
28370088 |
2017 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Large-scale sequence analyses of influenza viruses revealed that nonstructural 1 (NS1) proteins from avian influenza viruses have a conserved C-terminal ESEV amino acid motif, while NS1 proteins from typical human influenza viruses have a C-terminal RSKV motif.
|
20410267 |
2010 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Live attenuated influenza vaccine with trunctated NS1 protein as a potential strategy will be extremely useful for improving immune efficacy.
|
26638027 |
2016 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site.
|
30024831 |
2018 |
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nonstructural protein 1 (NS1) proteins from avian influenza viruses like the 1918 pandemic NS1 are capable of inhibiting the key signaling integrator c-Abl (Abl1), resulting in massive cytopathic cell alterations.
|
25367299 |
2015 |