Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model. 16545418 2006
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Influenza viruses lacking the interferon (IFN)-antagonistic non-structural NS1 protein are strongly attenuated. 19726611 2009
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE Influenza virus surveillance to identify new mutations in the NS1 protein affecting innate immune responses and, as a consequence, the pathogenicity of the circulating viruses is highly relevant. 27535054 2016
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells. 28757142 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis. 31104825 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE NS1 protein of influenza virus is a virulence factor that counteracts Type I interferon (IFN)-mediated antiviral response by the host. 15054864 2004
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE ADAR1 editing activity was enhanced by both viruses through dengue virus NS3 and influenza virus NS1 proteins, suggesting a similar virus-host co-evolution. 23853584 2013
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Although the NS1 protein is known to play a role in immune modulation, no differences were detected in the limited innate immune response to LPAI virus infection. 31683727 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells. 11719449 2001
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines. 27750071 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. 12149435 2002
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 AlteredExpression disease BEFREE Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing. 29921878 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Here we provide one explanation for this restriction: the species specificity exhibited by the NS1 protein of influenza B virus (NS1B protein). 20093371 2010
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 AlteredExpression disease BEFREE Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein. 22174864 2011
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 AlteredExpression disease BEFREE However, the present results indicate that the influenza B virus NS1 protein (NS1-B) is unable to interact with RIG-I but engages in the formation of a RIG-I/TRIM25/NS1-B ternary complex. 27122586 2016
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 AlteredExpression disease BEFREE Human interactome of the influenza B virus NS1 protein. 28869005 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Human monoclonal ScFv specific to NS1 protein inhibits replication of influenza viruses across types and subtypes. 23928258 2013
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation. 31470040 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE In conclusion, our results indicate that influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production. 23209422 2012
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE In sum, our study uncovers the molecular basis of a major nuclear function of influenza NS1 protein that causes potent blockage of host gene expression and contributes to inhibition of host immunity. 31263181 2019
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Lactobacillus casei carrying the NS1 protein could be developed into a universal oral influenza vaccine since the NS1 is highly conserved among influenza viruses. 28370088 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Large-scale sequence analyses of influenza viruses revealed that nonstructural 1 (NS1) proteins from avian influenza viruses have a conserved C-terminal ESEV amino acid motif, while NS1 proteins from typical human influenza viruses have a C-terminal RSKV motif. 20410267 2010
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Live attenuated influenza vaccine with trunctated NS1 protein as a potential strategy will be extremely useful for improving immune efficacy. 26638027 2016
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site. 30024831 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 Biomarker disease BEFREE Nonstructural protein 1 (NS1) proteins from avian influenza viruses like the 1918 pandemic NS1 are capable of inhibiting the key signaling integrator c-Abl (Abl1), resulting in massive cytopathic cell alterations. 25367299 2015