Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE Influenza virus surveillance to identify new mutations in the NS1 protein affecting innate immune responses and, as a consequence, the pathogenicity of the circulating viruses is highly relevant. 27535054 2016
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells. 28757142 2017
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells. 11719449 2001
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. 30177761 2018
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection. 28003482 2017
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines. 27750071 2017
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Here we provide one explanation for this restriction: the species specificity exhibited by the NS1 protein of influenza B virus (NS1B protein). 20093371 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE We studied the safety and immunogenicity of an influenza strain lacking the NS1 gene (DeltaNS1-H1N1) in healthy volunteers.METHODS. 20039806 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The NS1 protein of influenza viruses is a major virulence factor and exerts its function through interacting with viral/cellular RNAs and proteins. 24418537 2014
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Our studies revealed an extensive diversity of influenza virus-specific CD4 T cells that includes T cells for each viral protein and for the unexpected immunogenicity of the NS1 protein. 19386707 2009
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Large-scale sequence analyses of influenza viruses revealed that nonstructural 1 (NS1) proteins from avian influenza viruses have a conserved C-terminal ESEV amino acid motif, while NS1 proteins from typical human influenza viruses have a C-terminal RSKV motif. 20410267 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Lactobacillus casei carrying the NS1 protein could be developed into a universal oral influenza vaccine since the NS1 is highly conserved among influenza viruses. 28370088 2017
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Roles of its virulence factor, NS1 protein in influenza virus infected neuron has yet to be explored. 28992616 2017
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The NS1 protein of influenza virus is a virulence element and the critical factor for regulation of the host immune response during virus infection. 31530680 2019
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I. 31843969 2020
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE We designed six primers targeting the matrix genes of influenza H1 and H3 and the NS1 gene of influenza B and developed a M-LAMP assay using a commercially available Master Mix and a real time fluorometer (Genie II, Optigene, UK) that displays real time amplification, time to positivity and amplicon annealing temperature (Tm). 23827787 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE In sum, our study uncovers the molecular basis of a major nuclear function of influenza NS1 protein that causes potent blockage of host gene expression and contributes to inhibition of host immunity. 31263181 2019
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE We propose that NS1 protein of both H5N1 and H11N1 subtypes of influenza viruses are capable of influencing host immune responses and possess necessary functionality to support apoptosis in host cells. 22866982 2012
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The fact that influenza A and influenza B virus NS1 proteins bind to NS1-I suggests that this cellular protein plays a role in the influenza virus life cycle. 8764047 1996
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site. 30024831 2018
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE These findings suggest that the NS1 protein plays a role in the regulation of splicing of influenza virus M1 mRNA. 21918006 2012
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Nonstructural protein 1 (NS1) proteins from avian influenza viruses like the 1918 pandemic NS1 are capable of inhibiting the key signaling integrator c-Abl (Abl1), resulting in massive cytopathic cell alterations. 25367299 2015
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Human monoclonal ScFv specific to NS1 protein inhibits replication of influenza viruses across types and subtypes. 23928258 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE NS1 protein of influenza virus is a virulence factor that counteracts Type I interferon (IFN)-mediated antiviral response by the host. 15054864 2004
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains present in multiple host proteins, whereas no such motif is found in the NS1 homologues of seasonal human virus strains. 20686040 2010