| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | Cultured peripheral blood monocytes of never smokers (NS) and smokers without (S) and with COPD (3 study populations, n = 36-37) were stimulated with extracts of Haemophilus influenzae, Staphylococcus aureus, or Streptococcus pneumoniae or with four different pathogen-associated molecular patterns (PAMPs). | 30929031 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Non-typeable Haemophilus influenza (NTHi) infection is common in COPD. | 28420398 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | We conclude that a clonally related group of strains of nontypeable H. influenzae that has two IgA1 protease genes (iga and igaB) is adapted for colonization and infection in COPD. | 21998721 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | This polyphenol concomitantly reduces NTHi viability, therefore highlighting its therapeutic potential against NTHi infection at the COPD airway. | 29038519 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. | 28195529 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Taken together, the evidence suggests that pneumococcal and influenza vaccinations can prevent community-acquired pneumonia and acute exacerbations in COPD patients, while pneumococcal vaccination early in the course of COPD could help maintain stable health status. | 29255353 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | At stable state, H influenzae is associated with increased airway inflammation in COPD. | 25103335 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | Initiatives to increase vaccination uptake and early use of antiviral agents among patients with COPD could reduce influenza-related hospitalization and critical illness and improve health-care costs in this vulnerable population. | 30616737 | 2019 |