Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 GeneticVariation disease BEFREE On the contrary, the presence of the TLR4-T399I polymorphism was associated with a 2-fold decreased risk of Haemophilus influenzae carriage (OR = 0.38, 95% CI = 0.15 to 0.96, P = 0.038). 21159925 2011
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells. 28757142 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. 30177761 2018
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells. 11719449 2001
Entrez Id: 116442
Gene Symbol: RAB39B
RAB39B
0.100 GeneticVariation disease BEFREE These lncRNAs were also induced by other two influenza H1N1 virus strains (A/WSN/1933 and A/Oklahoma/3052/09) and interferon β1. 30669933 2019
Entrez Id: 64006
Gene Symbol: ERVK-6
ERVK-6
0.100 GeneticVariation disease BEFREE The hu-mAbs were designed for targeting a human B-cell epitope (<sup>180</sup>WGIHHPPNSKEQ QNLY<sup>195</sup>) of hemagglutinin (HA) envelope protein of PR8/A/34 (H1N1) virus with high homology among seven influenza type A viruses. 29135340 2018
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 GeneticVariation disease BEFREE Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells. 31305236 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 GeneticVariation disease BEFREE TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00). 24282567 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain. 30177761 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation disease BEFREE The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05). 31196204 2019
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE NS1 mutations D189N and V194I impaired the ability of the NS1 protein to inhibit general gene expression, and recombinant viruses harboring these mutations were attenuated in a mouse model of influenza infection. 28003482 2017
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines. 27750071 2017
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells. 11719449 2001
Entrez Id: 5920
Gene Symbol: PLAAT4
PLAAT4
0.100 GeneticVariation disease BEFREE We suggest that these RIG-I variants may have contributed to severe influenza in this patient and advocate that RIG-I variants should be sought in future studies of genetic factors influencing single-stranded RNA virus infections. 29453856 2018
Entrez Id: 10625
Gene Symbol: IVNS1ABP
IVNS1ABP
0.100 GeneticVariation disease BEFREE Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines. 27750071 2017
Entrez Id: 54938
Gene Symbol: SARS2
SARS2
0.100 GeneticVariation disease BEFREE This study used a broad capture, rapid and sensitive method (multiplex PCR assay) to detect 20 different respiratory pathogens including influenza A subtypes H1, H3, and H5; influenza B; parainfluenza types 1, 2, 3, and 4; respiratory syncytial virus (RSV) groups A and B; adenoviruses; human rhinoviruses; enteroviruses; human metapneumoviruses; human coronaviruses OC43, 229E, and SARS-CoV; Chlamydophila pneumoniae; Legionella pneumophila; and Mycoplasma pneumoniae; from respiratory specimens of 475 children hospitalized over a 12-month period for acute respiratory tract infections. 19031443 2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation disease BEFREE Thus, the presence of IL1B-31*C allele plus the presence of S. aureus and/or H. influenzae could be related to the development of tonsillitis in this particular Mexican population. 28542534 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 GeneticVariation disease BEFREE The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05). 31196204 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE We compared the prevalence of 8 polymorphisms in the tumor necrosis factor and mannose-binding lectin genes among 105 children and young adults with fatal influenza with US population estimates and determined in subanalyses whether these polymorphisms were associated with sudden death and bacterial co-infection among persons with fatal influenza. 22172537 2011
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children. 20804371 2010
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.090 GeneticVariation disease BEFREE The exchange of most 1918 influenza virus genes with seasonal influenza H1N1 virus genes did not alter the virulence of the 1918 virus; however, substitution of the hemagglutinin (HA), neuraminidase (NA), or polymerase subunit PB1 genes significantly affected the ability of this virus to cause severe disease in mice. 18287069 2008
Entrez Id: 51284
Gene Symbol: TLR7
TLR7
0.090 GeneticVariation disease BEFREE To analyze the immunogenicity of these domains, we used plasmacytoid dendritic cells (pDCs). pDCs express pattern recognition receptors, including Toll-like receptor 7 (TLR7), which recognizes guanosine- and uridine-rich viral single-stranded RNA (ssRNA), including influenza virus ssRNA. 21307198 2011
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.090 GeneticVariation disease BEFREE A ts+ ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. 17872525 2007
Entrez Id: 110006328
Gene Symbol: ERVK-32
ERVK-32
0.090 GeneticVariation disease BEFREE The hu-mAbs were designed for targeting a human B-cell epitope (<sup>180</sup>WGIHHPPNSKEQ QNLY<sup>195</sup>) of hemagglutinin (HA) envelope protein of PR8/A/34 (H1N1) virus with high homology among seven influenza type A viruses. 29135340 2018
Entrez Id: 55193
Gene Symbol: PBRM1
PBRM1
0.090 GeneticVariation disease BEFREE We also demonstrated that avian influenza viruses carrying the PB1 and PB2 mutations could be further attenuated by stably introducing a hemagglutinin (HA) epitope tag in the PB1 gene. 20181702 2010