|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This phenomenon occurs with multiple strains of IAV, is dependent on influenza NS1 protein, and can be modulated by SUMOylation of an intrinsically disordered region (IDR) of NS1 expressed by the 1918 pandemic IAV strain.
|
30177761 |
2018 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response.
|
10846107 |
2000 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human monoclonal ScFv specific to NS1 protein inhibits replication of influenza viruses across types and subtypes.
|
23928258 |
2013 |
|
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein.
|
22174864 |
2011 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unlike other influenza viruses, engineering truncations hypothesized to reduce interferon antagonism into the NS1 protein didn't attenuate bat-influenza.
|
25275541 |
2014 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways.
|
19706713 |
2009 |
|
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.
|
29921878 |
2018 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza viruses lacking the interferon (IFN)-antagonistic non-structural NS1 protein are strongly attenuated.
|
19726611 |
2009 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results indicate that influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production.
|
23209422 |
2012 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lactobacillus casei carrying the NS1 protein could be developed into a universal oral influenza vaccine since the NS1 is highly conserved among influenza viruses.
|
28370088 |
2017 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza.
|
12149435 |
2002 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site.
|
30024831 |
2018 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Live attenuated influenza vaccine with trunctated NS1 protein as a potential strategy will be extremely useful for improving immune efficacy.
|
26638027 |
2016 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation.
|
31470040 |
2019 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our studies revealed an extensive diversity of influenza virus-specific CD4 T cells that includes T cells for each viral protein and for the unexpected immunogenicity of the NS1 protein.
|
19386707 |
2009 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, DP<sub>92-93</sub> in the NS1 protein may confer a disadvantage to Influenza B viruses circulating in the human population and interestingly the low frequency of DP<sub>92-93</sub>detection in the NS1 protein since 2004 is consistent with this suggestion.
|
28348873 |
2016 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells.
|
11719449 |
2001 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines.
|
27750071 |
2017 |
|
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs.
|
30538201 |
2018 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nonstructural protein 1 (NS1) proteins from avian influenza viruses like the 1918 pandemic NS1 are capable of inhibiting the key signaling integrator c-Abl (Abl1), resulting in massive cytopathic cell alterations.
|
25367299 |
2015 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Roles of its virulence factor, NS1 protein in influenza virus infected neuron has yet to be explored.
|
28992616 |
2017 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
NS1 protein of influenza virus is a virulence factor that counteracts Type I interferon (IFN)-mediated antiviral response by the host.
|
15054864 |
2004 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains present in multiple host proteins, whereas no such motif is found in the NS1 homologues of seasonal human virus strains.
|
20686040 |
2010 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we provide one explanation for this restriction: the species specificity exhibited by the NS1 protein of influenza B virus (NS1B protein).
|
20093371 |
2010 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model.
|
16545418 |
2006 |