Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE We designed six primers targeting the matrix genes of influenza H1 and H3 and the NS1 gene of influenza B and developed a M-LAMP assay using a commercially available Master Mix and a real time fluorometer (Genie II, Optigene, UK) that displays real time amplification, time to positivity and amplicon annealing temperature (Tm). 23827787 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Human monoclonal ScFv specific to NS1 protein inhibits replication of influenza viruses across types and subtypes. 23928258 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE To this end, we compared autophagy in cells infected with wild-type (WT) influenza virus and virus lacking the NS1 gene (delNS1 virus). 24027311 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE ADAR1 editing activity was enhanced by both viruses through dengue virus NS3 and influenza virus NS1 proteins, suggesting a similar virus-host co-evolution. 23853584 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The influenza virus NS1 protein as a therapeutic target. 23796981 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE We propose that NS1 protein of both H5N1 and H11N1 subtypes of influenza viruses are capable of influencing host immune responses and possess necessary functionality to support apoptosis in host cells. 22866982 2012
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE These findings suggest that the NS1 protein plays a role in the regulation of splicing of influenza virus M1 mRNA. 21918006 2012
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE In conclusion, our results indicate that influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production. 23209422 2012
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 AlteredExpression disease BEFREE Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein. 22174864 2011
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation. 21163951 2011
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The C-terminal tail of influenza virus NS1 protein constitutes a nucleolar localization signal (NoLS) and is the binding domain of the cellular pre-mRNA processing protein, poly(A)-binding protein II (PABII). 22022552 2011
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE This study aims at improving our understanding on the pathogenic mechanism of influenza viruses, in particular the role of non-structural (NS1) protein in inducing pro-inflammatory and apoptotic responses. 22185562 2011
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Here we provide one explanation for this restriction: the species specificity exhibited by the NS1 protein of influenza B virus (NS1B protein). 20093371 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE We studied the safety and immunogenicity of an influenza strain lacking the NS1 gene (DeltaNS1-H1N1) in healthy volunteers.METHODS. 20039806 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Large-scale sequence analyses of influenza viruses revealed that nonstructural 1 (NS1) proteins from avian influenza viruses have a conserved C-terminal ESEV amino acid motif, while NS1 proteins from typical human influenza viruses have a C-terminal RSKV motif. 20410267 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains present in multiple host proteins, whereas no such motif is found in the NS1 homologues of seasonal human virus strains. 20686040 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Our studies revealed an extensive diversity of influenza virus-specific CD4 T cells that includes T cells for each viral protein and for the unexpected immunogenicity of the NS1 protein. 19386707 2009
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways. 19706713 2009
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Influenza viruses lacking the interferon (IFN)-antagonistic non-structural NS1 protein are strongly attenuated. 19726611 2009
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model. 16545418 2006
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE NS1 protein of influenza virus is a virulence factor that counteracts Type I interferon (IFN)-mediated antiviral response by the host. 15054864 2004
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. 12149435 2002
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 GeneticVariation disease BEFREE As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells. 11719449 2001
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response. 10846107 2000
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The fact that influenza A and influenza B virus NS1 proteins bind to NS1-I suggests that this cellular protein plays a role in the influenza virus life cycle. 8764047 1996