Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. 12149435 2002
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Although the NS1 protein is known to play a role in immune modulation, no differences were detected in the limited innate immune response to LPAI virus infection. 31683727 2019
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation. 31470040 2019
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Thus, DP<sub>92-93</sub> in the NS1 protein may confer a disadvantage to Influenza B viruses circulating in the human population and interestingly the low frequency of DP<sub>92-93</sub>detection in the NS1 protein since 2004 is consistent with this suggestion. 28348873 2016
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE To this end, we compared autophagy in cells infected with wild-type (WT) influenza virus and virus lacking the NS1 gene (delNS1 virus). 24027311 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE ADAR1 editing activity was enhanced by both viruses through dengue virus NS3 and influenza virus NS1 proteins, suggesting a similar virus-host co-evolution. 23853584 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Viral proteins such as the NS1 protein of Influenza virus A act upstream of the pathway while other viral proteins such as Theiler's virus L* protein act downstream. 26231767 2015
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE SHP2 deficiency promotes Staphylococcus aureus pneumonia following influenza infection. 31782850 2020
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The results of this study improve our understanding of C-terminal region function for NS1 proteins of influenza viruses. 30322535 2018
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The influenza virus NS1 protein as a therapeutic target. 23796981 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways. 19706713 2009
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation. 21163951 2011
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE The C-terminal tail of influenza virus NS1 protein constitutes a nucleolar localization signal (NoLS) and is the binding domain of the cellular pre-mRNA processing protein, poly(A)-binding protein II (PABII). 22022552 2011
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE This study aims at improving our understanding on the pathogenic mechanism of influenza viruses, in particular the role of non-structural (NS1) protein in inducing pro-inflammatory and apoptotic responses. 22185562 2011
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Influenza viruses lacking the interferon (IFN)-antagonistic non-structural NS1 protein are strongly attenuated. 19726611 2009
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Unlike other influenza viruses, engineering truncations hypothesized to reduce interferon antagonism into the NS1 protein didn't attenuate bat-influenza. 25275541 2014
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis. 31104825 2019
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Live attenuated influenza vaccine with trunctated NS1 protein as a potential strategy will be extremely useful for improving immune efficacy. 26638027 2016
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response. 10846107 2000
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE In conclusion, our results indicate that influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production. 23209422 2012
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 Biomarker disease BEFREE Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model. 16545418 2006
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 AlteredExpression disease BEFREE Human interactome of the influenza B virus NS1 protein. 28869005 2017
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 AlteredExpression disease BEFREE The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs. 30538201 2018
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 AlteredExpression disease BEFREE However, the present results indicate that the influenza B virus NS1 protein (NS1-B) is unable to interact with RIG-I but engages in the formation of a RIG-I/TRIM25/NS1-B ternary complex. 27122586 2016
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.100 AlteredExpression disease BEFREE Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein. 22174864 2011