Transcriptomic analysis of human IL-7 receptor alpha <sup>low</sup> and <sup>high</sup> effector memory CD8<sup>+</sup> T cells reveals an age-associated signature linked to influenza vaccine response in older adults.
Blockade of IL-7 within the lungs of IFN-γ(-/-) mice restored the contraction of influenza virus-specific CD8 T cells, indicating that IL-7R is important for survival and is not simply a consequence of the lack of IFN-γ signaling.