Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 AlteredExpression disease BEFREE Strikingly no differences were observed between these two groups, while plasma from acute influenza infection revealed significantly higher plasma levels of both IFNα and IFNβ proteins. 31508378 2019
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE IFN-Alpha1 antisense RNA represses human influenza A virus growth in a guinea pig system. 30844714 2019
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 AlteredExpression disease BEFREE <i>cpIFNA1</i> will enable us to perform a proof-of-concept experiment to verify that IFN-Alpha1 AS increases <i>cpIFNA1</i> mRNA levels, resulting in inhibition of influenza virus proliferation <i>in vivo</i>. 30844713 2019
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE However, neutrophil uptake of MRSA and <i>S. pneumoniae</i> was significantly reduced upon IFN-λ treatment during influenza superinfection <i>in vivo</i> Together, these data support the theory that IFN-λ decreases neutrophil motility and function in the influenza-infected lung, which increases the bacterial burden during superinfection. 30804099 2019
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 AlteredExpression disease BEFREE Those admitted with influenza tend to be female with mild serum inflammatory responses, increased serum IFN-α levels and good clinical outcomes. 31391224 2019
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE Life-threatening pulmonary influenza can be caused by inborn errors of type I and III IFN immunity. 30143481 2018
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE The IFN response was efficiently stimulated in these cells following infection with other viruses; the differential IFN response we observe with influenza viruses is therefore not cell specific but is likely due to differences in the nature of the infecting virus particles and their subsequent replication. 27983470 2017
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 AlteredExpression disease BEFREE Although our knowledge on the role of cellular lncRNAs for influenza virus replication and pathogenesis is still at its infancy, several lncRNAs have been described to influence the cell innate response to the virus by altering the histone modification at specific sites, by interaction with specific transcription factors or directly stimulating in cis the expression of specific IFN-induced genes. 26321158 2016
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE Recently however, human IRF7 was shown to be essential for IFN-α/β- and IFN-λ-dependent protective immunity against primary influenza in vivo, as inferred from a patient with life-threatening influenza revealed to be IRF7-deficient by whole exome sequencing. 26761402 2016
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 AlteredExpression disease BEFREE We show that influenza B virus induces IRF3 activation, leading to IFN gene expression after viral RNPs (vRNPs) are released into the cytosol and are recognized by RIG-I receptor, meaning that the incoming influenza B virus is already able to activate IFN gene expression. 26378160 2015
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE We also identified a common variant in IRF7 that is associated in trans with type I IFN induction in response to influenza infection. 24604203 2014
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 AlteredExpression disease BEFREE Levels of virus along with IFN-β and IFN-λ and IFN-stimulated gene expression (tracked by 2'-5'-oligoadenylate synthetase 1 and myxovirus (influenza virus) resistance 1 mRNA) were determined up to 72 hours postinoculation. 25216987 2014
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE Influenza was associated with overexpression of 20 genes, including those encoding the cytokines tumor necrosis factor and IL-12; the kinases MEK, TBK-1, and STAT-1; the apoptosis proteins caspase-8 and caspase-10; the influenza double-stranded RNA receptor RIG-I and its downstream effector MAVS; and pyrin, an IFN-stimulated protein involved in influenza resistance. 24641803 2014
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE IFN α receptor (IFNAR) knock-out (KO) mice exhibited increased mortality and morbidity with higher viral load after infection with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) compared with wild-type (WT) mice, though the viruses were finally eliminated in both groups. 23721943 2013
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 AlteredExpression disease BEFREE We also found that IFNα-Receptor knockout mice failed to induce Dll1 expression on lung macrophages and had enhanced mortality during influenza virus infection. 22072963 2011
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE However, the mRNA level of a single IFN-stimulated gene, MxA (myxovirus resistance A), the IFN-stimulated gene known to be critical in blocking influenza virus replication, was significantly lower in the tracheal lavages of untreated monkeys than in the oseltamivir-treated monkeys (p = 0.05). 18250448 2008
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.100 Biomarker disease BEFREE We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replication in a vaccination/challenge mouse model. 17240000 2007