| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | Biomarker | group | BEFREE | A key player in the pathogenetic process leading to the enteropathy is played by a protein called transglutaminase 2 (TG2), which is able to enzymatically modify gluten-derived gliadin peptides. | 27263022 | 2019 | ||||
|
0.060 | Biomarker | group | BEFREE | It is demonstrated that disulfiram, a relatively safe oral thiuram disulfide, is a fairly potent TG2 inhibitor ( k<sub>inh</sub>/ K<sub>i</sub> = 8.3 mM<sup>-1</sup> min<sup>-1</sup>) and may therefore provide a practical tool for clinically validating this emerging therapeutic target in intestinal disorders such as celiac disease. | 29570977 | 2018 | ||||
|
0.060 | Biomarker | group | BEFREE | Nearly 1 in 5 children with celiac disease in our population had persistent enteropathy despite maintaining a gluten-free diet and immunoglobulin A tTG was not an accurate marker of mucosal recovery. | 28112686 | 2017 | ||||
|
0.060 | Biomarker | group | BEFREE | A hallmark of the gluten-driven enteropathy celiac disease is autoantibody production towards the enzyme transglutaminase 2 (TG2) that catalyzes the formation of covalent protein-protein cross-links. | 26244572 | 2015 | ||||
|
0.060 | Biomarker | group | BEFREE | Coeliac disease (CD), an enteropathy caused by cereal gluten ingestion, is characterized by CD4(+) T cells recognizing deamidated gluten and by antibodies reactive to gluten or the self-antigen transglutaminase 2 (TG2). | 24909383 | 2014 | ||||
|
0.060 | GeneticVariation | group | BEFREE | Deamidated gliadin-IgA (83% vs. 22%), deamidated gliadin-IgG (50% vs. 3%), tissue transglutaminase-IgA (78% vs. 11%), and anti-endomysial-IgA (70% vs. 0%), were significantly more positive in ataxia/neuropathy patients with celiac disease versus those without enteropathy (P<0.001). | 21056914 | 2011 |