Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Stimulation with Eubacterium limosum resulted in a significantly decreased IL-10 release in HC compared to PI-IBS patients (p < 0.05) and a tendency to decreased IL-13 release in HC compared to PI-IBS patients (p = 0.07). 26366730 2016
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE IL-10 and TNF-alpha polymorphisms in subjects with irritable bowel syndrome in Mexico. 24206549 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE In this study, we first reproduced the recovery-recurrence periods observed in IBS-patients in a new chronic model characterized by 2 episodes of DiNitro-BenzeneSulfonic-acid (DNBS)-challenge and we tested the effects of a recombinant strain of L. lactis secreting IL-10 under a Stress-Inducible Controlled Expression (SICE) system. 24732667 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: a meta-analysis. 24409078 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE This meta-analysis indicates a role for IL-10 polymorphisms in IBS in general and TNF in Asian populations. 22897390 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE S100A expression and interleukin-10 polymorphisms are associated with ulcerative colitis and diarrhea predominant irritable bowel syndrome. 23595519 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis. 22287022 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE An association of certain polymorphisms of IL-8 and IL-10 in IBS patients compared to controls was demonstrated, suggesting a role of these cytokine SNPs in the pathophysiology of IBS. 22740130 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Production of IL10 in response to bacterial motifs was normal in all IBD patients. 21519361 2011
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Multifactor dimensionality reduction analysis revealed that there were no significant interactions of GNB3, IL-10, and TNF-alpha gene variants with susceptibility to IBS (P > 0.05). 20337945 2010
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS. 20177758 2010
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Genetic association studies with IBS symptom phenotype have generally provided inconsistent results for many candidate genes investigated, such as SLC6A4, GNB3, and IL-10. 19655247 2009
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome. 16279907 2005
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Interleukin-10 polymorphisms in Spanish patients with IBD. 16043989 2005
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? 12477767 2003
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease CTD_human Rapid development of colitis in NSAID-treated IL-10-deficient mice. 12404228 2002
Entrez Id: 7177
Gene Symbol: TPSAB1
TPSAB1
0.300 Biomarker disease CTD_human Thus, our findings link duplications in TPSAB1 with irritable bowel syndrome, cutaneous complaints, connective tissue abnormalities, and dysautonomia. 27749843 2016
Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
0.220 GeneticVariation disease BEFREE Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS. 26808377 2016
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.220 Biomarker disease BEFREE Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome. 26808377 2016
Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
0.220 GeneticVariation disease BEFREE Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome. 22957021 2013
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.220 AlteredExpression disease BEFREE We examined CRF2 gene and protein expression in the distal/sigmoid colonic mucosal biopsies from healthy subjects and patients with UC (active or disease in remission), human immunodeficiency virus (HIV) and functional bowel disease (FBD) by reverse transcription-polymerase chain reaction and immunofluorescence. 23539366 2013
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.220 Biomarker disease RGD Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors. 20096320 2010
Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
0.220 Biomarker disease RGD Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors. 20096320 2010
Entrez Id: 3363
Gene Symbol: HTR7
HTR7
0.210 AlteredExpression disease BEFREE The results reveal that (1) IBS-D and UC are related to visceral sensitivity pathogenesis and the clinical manifestations of these conditions and (2) the observed differences in visceral hypersensitivity are possibly due to differences in levels of the 5-HT7 receptor, a component of the 5-HT signaling pathway. 27022227 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.210 Biomarker disease RGD Probiotics VSL#3 protect against development of visceral pain in murine model of irritable bowel syndrome. 23691109 2014