Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Two IL-10 single nucleotide polymorphisms (rs1800871 and rs1800896) were detected in 120 patients with IBS-D and 144 healthy controls (HC) using SNaPshot. 31205078 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE IBD in infants and children under 2 years of age is life-threatening when patients with IL-10R mutations do not receive allogeneic HSCT. 30900524 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE No evidence supported the association of GNβ3 rs5443, TNFα rs1800629, and IL10 rs1800871 to IBS in this study. 31615448 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE When comparing IBS subtypes, TNFα and IL-17 were significantly (P<0.05) higher, and IL-10 was significantly (P<0.05) lower in diarrhea predominant IBS (IBS-D) compared to HCs, whereas the inflammatory cytokine profile of other subtypes more closely resembled that of HCs. 28506572 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE The diverse roles of IL-10 in IBS are reviewed here. 28237672 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE IBS-SSS was associated with high tumor necrosis factor and low IL-10 in the CSF; pc = 0.341 and <i>p</i> = 0.009 and pc = -0.299 and <i>p</i> = 0.023, respectively. 29201045 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE Mucosal mRNA expression of IL-10 and FOXP3 tended to be decreased in IBS patients. 27272011 2016
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Stimulation with Eubacterium limosum resulted in a significantly decreased IL-10 release in HC compared to PI-IBS patients (p < 0.05) and a tendency to decreased IL-13 release in HC compared to PI-IBS patients (p = 0.07). 26366730 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios (OR) with 95% confidence interval (CI). 24409078 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE in this group of volunteers in Mexico, the frequency of the IL-10 (-1082G/A) and TNF-alpha (-308G/A) genotypes was similar in IBS and controls. 24206549 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE The IL10-819 CC is a candidate genotype for both IBS and UC in Japanese. 23595519 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE An association of certain polymorphisms of IL-8 and IL-10 in IBS patients compared to controls was demonstrated, suggesting a role of these cytokine SNPs in the pathophysiology of IBS. 22740130 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE High producer IL-10 (-1082 G/G; OR: 0.64 [95% CI: 0.48-0.87]) was significantly associated with a decreased risk of IBS. 22897390 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Our results suggest that some IL-8 and IL-10 SNPs could change individual susceptibility increasing the relative risk in the development of IBS in Blastocystis carriers. 22287022 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Production of IL10 in response to bacterial motifs was normal in all IBD patients. 21519361 2011
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Multifactor dimensionality reduction analysis revealed that there were no significant interactions of GNB3, IL-10, and TNF-alpha gene variants with susceptibility to IBS (P > 0.05). 20337945 2010
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS. 20177758 2010
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Genetic association studies with IBS symptom phenotype have generally provided inconsistent results for many candidate genes investigated, such as SLC6A4, GNB3, and IL-10. 19655247 2009
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Possession of a high producer TNF-alpha and a low producer IL-10 genotype were significantly more prevalent in IBS (9%) versus controls (3%, p= 0.035; OR 3.11, 95% CI 1.03-9.36) and in diarrhea (20%) compared to other IBS subtypes (<4%, p= 0.026). 16279907 2005
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Interleukin-10 polymorphisms in Spanish patients with IBD. 16043989 2005
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE Patients with irritable bowel syndrome had significantly reduced frequencies of the high producer genotype for interleukin 10 than controls (21% v 32%; p=0.003). 12477767 2003
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease CTD_human Rapid development of colitis in NSAID-treated IL-10-deficient mice. 12404228 2002
Entrez Id: 7177
Gene Symbol: TPSAB1
TPSAB1
0.310 GeneticVariation disease BEFREE Thus, our findings link duplications in TPSAB1 with irritable bowel syndrome, cutaneous complaints, connective tissue abnormalities, and dysautonomia. 27749843 2016
Entrez Id: 7177
Gene Symbol: TPSAB1
TPSAB1
0.310 Biomarker disease CTD_human Thus, our findings link duplications in TPSAB1 with irritable bowel syndrome, cutaneous complaints, connective tissue abnormalities, and dysautonomia. 27749843 2016
Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
0.300 Biomarker disease GENOMICS_ENGLAND Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions. 21143118 2011