The present study indicates that the expression of Sp1 and KLF6 is developmentally regulated, providing a basis for further investigations on the regulation of the Sp1 and KLF6 gene during the course of corneal development and in corneal diseases such as keratoconus.
A global increased expression of the transcription factor KLF6 in terms of mRNAs and proteins was observed in total cornea and/or the epithelium in a substantial number of the keratoconus specimens.
A global increased expression of the transcription factor KLF6 in terms of mRNAs and proteins was observed in total cornea and/or the epithelium in a substantial number of the keratoconus specimens.