Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 Biomarker disease BEFREE Here, we review the pathobiology of DM and KC in the context of corneal structure, the epidemiology behind the inverse correlation of DM and KC development, and the chemical mechanisms of lysyl oxidase-mediated crosslinking, advanced glycation end product-mediated crosslinking, and photoreactive riboflavin-mediated corneal crosslinking. 31614631 2019
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 AlteredExpression disease BEFREE Outcomes of Corneal Cross-Linking Correlate With Cone-Specific Lysyl Oxidase Expression in Patients With Keratoconus. 29215396 2018
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 AlteredExpression disease BEFREE We observed a significant reduction in LOX transcript levels in KC corneal epithelia, and LOX activity in KC tears correlated with disease severity. 25593510 2015
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 GeneticVariation disease BEFREE SNP rs1324183 located in MPDZ-NF1B was associated with an increased risk of KC (OR=3.108, 95% CI=1.366-7.072, p=0.005), and SNP rs2956540 in the LOX gene may confer a reduced risk of KC with a borderline p value in our population (OR=0.664, 95% CI=0.447-0.986, p=0.042). 25675348 2015
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 GeneticVariation disease BEFREE The aim of our study was to validate the effects of seven single-nucleotide polymorphisms (SNPs) within LOX and HGF over KC. 25735481 2015
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 GeneticVariation disease BEFREE This meta-analysis suggested that two LOX variants, rs2956540 and rs10519694, may affect individual susceptibility to keratoconus, while distinct heterogeneity existed within this locus. 26713757 2015
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 GeneticVariation disease BEFREE The current study aimed to investigate the possible associations between two LOX polymorphisms, rs1800449 and rs2288393, and susceptibility to keratoconus. 24502826 2015
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 AlteredExpression disease BEFREE Altered expression and/or activity of lysyl oxidase, a critical enzyme of the biogenesis of connective tissue detected in KC corneas, may weaken covalent bonds between collagen and elastin fibrils, what may lead to biomechanical deterioration of the cornea. 24644548 2014
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 Biomarker disease BEFREE Similarly, recent genome-wide association studies in case-controlled cohorts have identified common variations in and around HGF, RAB3GAP1 and LOX as candidate risk factors for keratoconus. 23387289 2013
Entrez Id: 4015
Gene Symbol: LOX
LOX
0.100 GeneticVariation disease BEFREE Association results were analyzed of single-nucleotide polymorphisms (SNPs) in the LOX gene from a Genome-Wide Association Study (GWAS) investigation in two independent panels of patients with keratoconus and controls and in keratoconus families. 22661479 2012