| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | GeneticVariation | group | BEFREE | This IL1RN SNP tags three other variants, none of which have previously been reported to be associated with renal disease. | 20551628 | 2010 | ||||
|
0.370 | GeneticVariation | group | BEFREE | While a significant association be-tween macroalbuminuria and CRP could be observed (p<0,015), no associations were found between IL-6G(-174)C or IL1RA genotype and any stage of nephropathy. | 17286233 | 2007 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Further, CT, TT genotypes of IL-1beta (-511C/T) and 1/2 genotype of IL-1RN (VNTR) were found to be associated with risk of complications particularly with nephropathy in T2DM. | 17069782 | 2007 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Our results showed that IL1RN (rs315952) was significantly associated with SLE in patients without renal disorder in the family-based study, after disease stratification, but was not significantly associated with SLE in the case-control study. | 17176440 | 2006 | ||||
|
0.370 | Biomarker | group | BEFREE | The allelic frequency of IL1RN*2 was also higher in cases than in controls without nephropathy (8.4 vs. 2.8 %, p < 0.05). | 15286433 | 2004 | ||||
|
0.370 | GeneticVariation | group | BEFREE | In a previously validated case-control study from Northern Ireland, consisting of 95 patients with insulin-dependent (type 1) diabetes and nephropathy (cases) and 96 patients with insulin-dependent (type 1) diabetes without nephropathy (controls), the authors performed PCR-based genotyping of specific DNA polymorphisms within the interleukin 1A, interleukin 1B, interleukin 1 (type 1) receptor and interleukin 1 receptor antagonist genes. | 10049523 | 1998 | ||||
|
0.370 | Therapeutic | group | CTD_human | Interleukin-1 receptor antagonist modulates the progression of a spontaneously occurring IgA nephropathy in mice. | 9370186 | 1997 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus. | 8786086 | 1996 |