Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.310 | Biomarker | disease | BEFREE | Median levels of 5 biomarkers were significantly higher in AKI cases than controls at 1-3 days before AKI onset (all µg/mmol): clusterin [58(8-411) versus 7(3-17)], beta-2-microglobulin [1632(913-3823) versus 253(61-791)], KIM1 [0.16(0.13-0.76) versus 0.07(0.05-0.15)], MCP1 [0.40(0.16-1.90) versus 0.07(0.04-0.17)], and cystatin-C [33(27-2990) versus 11(7-19)], all p<0.05; their AUROC for AKI prediction were >0.80 (confidence intervals >0.50), with average accuracy highest for clusterin (86%), followed by beta-2-microglobulin, cystatin-C, MCP1, and KIM1 (57%) after cross-validation. | 31296157 | 2019 | ||||
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0.310 | Biomarker | disease | CTD_human | A Multiplatform Approach for the Discovery of Novel Drug-Induced Kidney Injury Biomarkers. | 28885000 | 2017 | ||||
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0.310 | Biomarker | disease | CTD_human | Evaluation of the relative performance of 12 urinary biomarkers for renal safety across 22 rat sensitivity and specificity studies. | 24361871 | 2014 | ||||
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0.310 | Biomarker | disease | CTD_human | Repeat oral dose toxicity studies of melamine in rats and monkeys. | 23052191 | 2013 | ||||
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0.310 | Biomarker | disease | CTD_human | Therefore, we comprehensively addressed the relationship between Ucr-correction and UFR-correction of ten urinary biomarkers N-acetyl-β-d-glucosaminidase (NAG), lactate dehydrogenase (LDH), total protein, albumin, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, clusterin, β(2)-microglobulin, cystatin-c and glutathione S-transferase-α in non-steady state situations such as AKI. | 22005293 | 2011 | ||||
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0.310 | Biomarker | disease | CTD_human | Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. | 20623750 | 2011 | ||||
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0.310 | Biomarker | disease | CTD_human | Performance of novel kidney biomarkers in preclinical toxicity studies. | 20118187 | 2010 |