Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | Biomarker | disease | BEFREE | The aim of this study was to evaluate the feasibility and capability of diffusion MRI and ET-1 to detect acute kidney injury by an operation simulating high-pressure renal pelvic perfusion, which is commonly used during ureteroscopic lithotripsy. | 31290588 | 2019 | ||||
|
0.360 | AlteredExpression | disease | BEFREE | The results indicate that mTORC1-JNK-dependent up-regulation of ECE1 elevated EDN1 in TSC1-knockout renal fibroblasts and contributed to improvement of renal function in Fibro-TSC1<sup>-/-</sup> mice with LPS-induced AKI. | 30185506 | 2018 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | AKI occurred in 26.5% of the 347 patients included in the analysis, and was independently associated with preoperative ET-1 (p = 0.008), body mass index (BMI) (p = 0.022), male gender (p = 0.005) and duration of CPB (p = 0.002). | 30229506 | 2018 | ||||
|
0.360 | Biomarker | disease | BEFREE | Moreover, TGF-β, vimentin, fibronectin and α-smooth muscle actin, biomarkers of fibrosis, and TNFα, IL6 and endothelin-1, biomarkers of inflammation, were upregulated in I/R induced AKI, primarily in heparanase transgenic mice, suggesting an adverse role of heparanase in the pathogenesis of AKI. | 28388547 | 2017 | ||||
|
0.360 | AlteredExpression | disease | BEFREE | Impaired tubulointerstitial expression of endothelin-1 and nitric oxide isoforms in donor kidney biopsies with postischemic acute renal failure. | 12973116 | 2003 | ||||
|
0.360 | Biomarker | disease | BEFREE | These findings indicate that ET-1 participates in the pathogenesis of acute tubular injury in glycerol-induced ARF and that ETA antagonist may be useful in the treatment of some types of human ARF. | 9694958 | 1998 | ||||
|
0.360 | Biomarker | disease | CTD_human | Altered expression of endothelin-1 and endothelial nitric oxide synthase in the juxtaglomerular apparatus of rats with HgCl2-induced acute renal failure. | 9788586 | 1998 |