Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.360 Biomarker disease BEFREE The aim of this study was to evaluate the feasibility and capability of diffusion MRI and ET-1 to detect acute kidney injury by an operation simulating high-pressure renal pelvic perfusion, which is commonly used during ureteroscopic lithotripsy. 31290588 2019
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.360 AlteredExpression disease BEFREE The results indicate that mTORC1-JNK-dependent up-regulation of ECE1 elevated EDN1 in TSC1-knockout renal fibroblasts and contributed to improvement of renal function in Fibro-TSC1<sup>-/-</sup> mice with LPS-induced AKI. 30185506 2018
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.360 GeneticVariation disease BEFREE AKI occurred in 26.5% of the 347 patients included in the analysis, and was independently associated with preoperative ET-1 (p = 0.008), body mass index (BMI) (p = 0.022), male gender (p = 0.005) and duration of CPB (p = 0.002). 30229506 2018
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.360 Biomarker disease BEFREE Moreover, TGF-β, vimentin, fibronectin and α-smooth muscle actin, biomarkers of fibrosis, and TNFα, IL6 and endothelin-1, biomarkers of inflammation, were upregulated in I/R induced AKI, primarily in heparanase transgenic mice, suggesting an adverse role of heparanase in the pathogenesis of AKI. 28388547 2017
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.360 AlteredExpression disease BEFREE Impaired tubulointerstitial expression of endothelin-1 and nitric oxide isoforms in donor kidney biopsies with postischemic acute renal failure. 12973116 2003
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.360 Biomarker disease BEFREE These findings indicate that ET-1 participates in the pathogenesis of acute tubular injury in glycerol-induced ARF and that ETA antagonist may be useful in the treatment of some types of human ARF. 9694958 1998
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.360 Biomarker disease CTD_human Altered expression of endothelin-1 and endothelial nitric oxide synthase in the juxtaglomerular apparatus of rats with HgCl2-induced acute renal failure. 9788586 1998