Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 AlteredExpression disease BEFREE Porous Se@SiO2 nanospheres attenuate cisplatin-induced acute kidney injury via activation of Sirt1. 31400413 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 AlteredExpression disease BEFREE Collectively, rhEPO suppressed LPS-induced cell apoptosis via AMPK/SIRT1 pathway mediated autophagy, and modulating their levels may serve as potential way in preventing AKI. 31383361 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 Biomarker disease BEFREE SIRT1 activation and p53 deacetylation might be identified as potential targets for attenuating premature renal senescence and retarding the progression of CKD post AKI. 30447351 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 AlteredExpression disease BEFREE CONCLUSIONS NLRP3 inflammasome could act as a critical regulator promoting the process of AKI induced by LPS, and the overexpression of SIRT1 might be able to suppress the activation of NLRP3 and therefore resist the kidney injury, showing promise to be used as a target in the treatment of sepsis-induced AKI. 30980521 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 Biomarker disease BEFREE In this study, we aimed to evaluate whether SRT1720, a potent and specific activator of Sirt1, could ameliorate cisplatin-induced AKI. 31431003 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 Biomarker disease BEFREE Protective effect of astaxanthin against contrast-induced acute kidney injury via SIRT1-p53 pathway in rats. 30456546 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 AlteredExpression disease BEFREE Astaxanthin attenuates contrast agent-induced acute kidney injury in vitro and in vivo via the regulation of SIRT1/FOXO3a expression. 29368247 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 Biomarker disease BEFREE GA prevented LPS-induced AKI by activating SIRT1 via inhibiting the NF-κB signaling pathway, providing new insights into the function and molecular mechanism of GA in AKI. 28852469 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 Biomarker disease BEFREE Res increases the survival rate of septic rats by inhibiting inflammatory factors to ease AKI and promotes NF-κB-P65 de-acetylation by upregulating SIRT1. 27837177 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.390 Biomarker disease CTD_human Sirt1 was induced to a greater extent in rats with severe ARF. 21416250 2011