Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.350 | Biomarker | disease | BEFREE | Growth differentiation factor-15 (GDF15), leucine-rich alpha-2-glycoprotein 1 (LRG1), and secreted phosphoprotein 1 (SPP1/ osteopontin, OPN) were identified as potential candidate markers by proteomic analysis and were validated by ELISA in another 30 patients and in a CP-induced AKI mouse model. | 31629959 | 2020 | ||||
|
0.350 | Biomarker | disease | BEFREE | OPN levels were positively correlated to plasma creatinine (r = 0.401 with <i>p</i> = 0.0001), but this relation was not explained by the development of acute kidney injury (AKI), since no difference was found in OPN concentration between AKI and non-AKI patients. | 30781721 | 2019 | ||||
|
0.350 | GeneticVariation | disease | BEFREE | Six predictors were present in the final model: four (history of diabetes, blood urea nitrogen to creatinine ratio, C-reactive protein, and osteopontin) had a positive association with AKI risk, while two (CD5 antigen-like and Factor VII) had a negative association with AKI risk. | 30582197 | 2019 | ||||
|
0.350 | Biomarker | disease | BEFREE | Six other urine biomarkers urine albumin, urine beta2-microglobulin, urine kidney injury molecule-1, urine cystatin C, urine trefoil factor-3 and urine osteopontin either had minimal elevation, and/or minimal prediction for AKI stage 2/3 (AUC-ROC<0.7). | 31260445 | 2019 | ||||
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0.350 | Biomarker | disease | BEFREE | Administration of anti-OPN Ab may therefore serve as an immunomodulatory adjunct in the treatment of RIR-induced AKI. | 27504800 | 2017 | ||||
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0.350 | Biomarker | disease | CTD_human | Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. | 20623750 | 2011 | ||||
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0.350 | Biomarker | disease | CTD_human | OPN gene and protein expression is induced in both proximal and distal tubular cells during rat toxic ARF. | 11274264 | 2001 |