Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression disease BEFREE Decreased expression of transforming growth factor-β1 and α-smooth muscle actin contributes to the protection of lotensin against chronic renal failure in rats. 30371125 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease BEFREE <b>Aims/Hypothesis:</b> Transforming growth factor-beta (TGF-β1) plays an important regulatory role in the progression of chronic kidney failure. 30618784 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease BEFREE These results suggested that osthole protects against inflammation in a rat model of CRF via suppression of NF‑κB and TGF‑β1, and activation of PI3K/Akt/nuclear factor (erythroid‑derived 2)‑like 2 signaling. 28765904 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation disease BEFREE Our results conclude that TGF-β1 (rs1800470) may increase the risk of both ESRD and T2D in both populations, but TGF-β1 (rs1800469) provided risk for only ESRD in the population of Jammu and Kashmir. 25871499 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease BEFREE This study is the first prospective study to demonstrate that circulating TGF-β1-regulated miRNAs are deregulated early in T1D patients who are at risk for rapid progression to ESRD. 25931475 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression disease BEFREE Mean TGF-β1 protein levels were 2.7-fold lower in ESRD patients as compared to normal controls (p<0.001). 24113078 2014
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease BEFREE Phosphorylated NF-κB p65 was expressed and colocalized with p53, p21, β-galactosidase, TGF-β1, and α-SMA in the kidneys of chronic renal failure (CRF) rats. 21832251 2011
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease CTD_human Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation disease BEFREE Carriage of the TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG genotypes may increase susceptibility to ESRD in German patients with type 2 diabetes or glomerulonephritis. 17173255 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation disease BEFREE The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation. 17198270 2006
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation disease LHGDN The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation. 17198270 2006
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation disease LHGDN Transforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiency. 15942255 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation disease LHGDN This study aimed to evaluate the association of TGF-beta1 polymorphisms with chronic renal disease (CRD), and its progression to dialysis in a retrospective longitudinal study of an end-stage renal disease (ESRD) cohort. 15593053 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation disease BEFREE This study aimed to evaluate the association of TGF-beta1 polymorphisms with chronic renal disease (CRD), and its progression to dialysis in a retrospective longitudinal study of an end-stage renal disease (ESRD) cohort. 15593053 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation disease BEFREE Low TGF-beta1 serum levels are a risk factor for atherosclerosis disease in ESRD patients. 11786115 2002
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease RGD Only animals from the 1WIK group developed severe chronic renal failure, glomerulosclerosis, interstitial fibrosis, and upregulation of transforming growth factor-beta(1) (TGF-beta(1)) gene, which was associated with increased TGF-beta(1) protein expression in tubular epithelial cells, arterioles, and in areas of mononuclear interstitial cell infiltrate. 10919844 2000
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease BEFREE Transforming growth factor-beta1 (TGF-beta1) may play a major role in the pathogenesis of glomerulopathy and end-stage renal disease (ESRD). 11140698 2000
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression disease BEFREE (The use of ESRD patients as the study cohort eliminates renal function-dependent alterations in circulating levels of TGF-beta1 protein.) 9931116 1999
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease BEFREE Our observation that TGF-beta 1 is hyperexpressed in black ESRD patients suggests a mechanism for the increased prevalence of renal failure (since TGF-beta 1 hyperexpression can result in renal insufficiency in experimental models) among the black population. 9507209 1998