Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1201
Gene Symbol: CLN3
CLN3
0.500 Biomarker disease CTD_human
Entrez Id: 2055
Gene Symbol: CLN8
CLN8
0.200 Biomarker disease MGD Mapping of the motor neuron degeneration (Mnd) gene, a mouse model of amyotrophic lateral sclerosis (ALS). 1639406 1992
Entrez Id: 2055
Gene Symbol: CLN8
CLN8
0.200 Biomarker disease MGD Autosomal dominance in a late-onset motor neuron disease in the mouse. 3783318 1986
Entrez Id: 1509
Gene Symbol: CTSD
CTSD
0.200 Biomarker disease MGD Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. 7641679 1995
Entrez Id: 2055
Gene Symbol: CLN8
CLN8
0.200 Biomarker disease MGD Motor neuron degeneration of mice is a model of neuronal ceroid lipofuscinosis (Batten's disease). 7683855 1993
Entrez Id: 2055
Gene Symbol: CLN8
CLN8
0.200 Biomarker disease MGD Retinal degeneration in motor neuron degeneration (mnd) mutant mice. 8282051 1993
Entrez Id: 1509
Gene Symbol: CTSD
CTSD
0.200 Biomarker disease MGD Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. 9539769 1998
Entrez Id: 54982
Gene Symbol: CLN6
CLN6
0.830 Biomarker disease MGD Neuronal ceroid lipofuscinosis (nclf), a new disorder of the mouse linked to chromosome 9. 9600738 1998
Entrez Id: 2055
Gene Symbol: CLN8
CLN8
0.200 Biomarker disease MGD An early-onset congenic strain of the motor neuron degeneration (mnd) mouse. 10191135 1999
Entrez Id: 1200
Gene Symbol: TPP1
TPP1
0.500 Biomarker disease CTD_human Increased brain lysosomal pepstatin-insensitive proteinase activity in patients with neurodegenerative diseases. 10320038 1999
Entrez Id: 1201
Gene Symbol: CLN3
CLN3
0.500 Biomarker disease MGD A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease). 10440905 1999
Entrez Id: 1201
Gene Symbol: CLN3
CLN3
0.500 Biomarker disease MGD Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]. 10527801 1999
Entrez Id: 1509
Gene Symbol: CTSD
CTSD
0.200 Biomarker disease MGD Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. 10995834 2000
Entrez Id: 1509
Gene Symbol: CTSD
CTSD
0.200 Biomarker disease MGD Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. 11567042 2001
Entrez Id: 1200
Gene Symbol: TPP1
TPP1
0.500 Biomarker disease CTD_human Aminoglycoside-mediated suppression of nonsense mutations in late infantile neuronal ceroid lipofuscinosis. 11589009 2001
Entrez Id: 5538
Gene Symbol: PPT1
PPT1
0.200 Biomarker disease MGD Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. 11717424 2001
Entrez Id: 1182
Gene Symbol: CLCN3
CLCN3
0.200 Biomarker disease MGD CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. 12059962 2002
Entrez Id: 1201
Gene Symbol: CLN3
CLN3
0.500 Biomarker disease MGD Cln3(Deltaex7/8) knock-in mice with the common JNCL mutation exhibit progressive neurologic disease that begins before birth. 12374761 2002
Entrez Id: 1509
Gene Symbol: CTSD
CTSD
0.200 Biomarker disease MGD Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. 12676526 2003
Entrez Id: 4691
Gene Symbol: NCL
NCL
0.010 GeneticVariation disease BEFREE Autosomal dominant adult neuronal ceroid lipofuscinosis: a novel form of NCL with granular osmiophilic deposits without palmitoyl protein thioesterase 1 deficiency. 14655761 2003
Entrez Id: 1201
Gene Symbol: CLN3
CLN3
0.500 Biomarker disease MGD Altered gene expression in the eye of a mouse model for batten disease. 15326100 2004
Entrez Id: 1203
Gene Symbol: CLN5
CLN5
0.200 Biomarker disease MGD A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging. 15459177 2004
Entrez Id: 1200
Gene Symbol: TPP1
TPP1
0.500 Biomarker disease MGD A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration. 15483130 2004
Entrez Id: 1182
Gene Symbol: CLCN3
CLCN3
0.200 Biomarker disease MGD ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. 15504734 2005
Entrez Id: 5538
Gene Symbol: PPT1
PPT1
0.200 Biomarker disease MGD Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons. 15649713 2005