Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.010 AlteredExpression group BEFREE Developmental language disorder: Maternal stress level and behavioural difficulties of children with expressive and mixed receptive-expressive DLD. 30999162 2020
Entrez Id: 4205
Gene Symbol: MEF2A
MEF2A
0.010 Biomarker group BEFREE MEF2-regulated pathways were identified as potential candidate pathways in the etiology of DLD. 27016271 2016
Entrez Id: 113451
Gene Symbol: AZIN2
AZIN2
0.010 Biomarker group BEFREE Children with DLD showed a higher overall volume and higher ADC values for the left-hemispheric language related WM tracts. 29934818 2019
Entrez Id: 339896
Gene Symbol: GADL1
GADL1
0.010 Biomarker group BEFREE Children with DLD showed a higher overall volume and higher ADC values for the left-hemispheric language related WM tracts. 29934818 2019
Entrez Id: 26047
Gene Symbol: CNTNAP2
CNTNAP2
0.310 Biomarker group CTD_human CNTNAP2 variants affect early language development in the general population. 21310003 2011
Entrez Id: 3737
Gene Symbol: KCNA2
KCNA2
0.300 Biomarker group CTD_human De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. 25751627 2015
Entrez Id: 26047
Gene Symbol: CNTNAP2
CNTNAP2
0.310 Biomarker group CTD_human Deletion of 7q34-q36.2 in two siblings with mental retardation, language delay, primary amenorrhea, and dysmorphic features. 21082657 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.300 Biomarker group CTD_human Deletion of PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease. 9286463 1997
Entrez Id: 53335
Gene Symbol: BCL11A
BCL11A
0.300 Biomarker group CTD_human Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. 27120335 2016
Entrez Id: 93986
Gene Symbol: FOXP2
FOXP2
0.300 Biomarker group CTD_human Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. 27120335 2016
Entrez Id: 2903
Gene Symbol: GRIN2A
GRIN2A
0.300 Biomarker group CTD_human GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction. 23933820 2013
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.300 Biomarker group CTD_human Hemizygous deletions on chromosome 1p21.3 involving the DPYD gene in individuals with autism spectrum disorder. 21114665 2011
Entrez Id: 26047
Gene Symbol: CNTNAP2
CNTNAP2
0.310 GeneticVariation group BEFREE Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental language disorders, autism spectrum disorders, epilepsy, and schizophrenia. 19896112 2009
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.310 Biomarker group BEFREE Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental language disorders, autism spectrum disorders, epilepsy, and schizophrenia. 19896112 2009
Entrez Id: 85358
Gene Symbol: SHANK3
SHANK3
0.300 Biomarker group CTD_human Identification of a recurrent breakpoint within the SHANK3 gene in the 22q13.3 deletion syndrome. 16284256 2006
Entrez Id: 26047
Gene Symbol: CNTNAP2
CNTNAP2
0.310 Biomarker group CTD_human Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. 20157312 2011
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.310 Biomarker group CTD_human Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. 20157312 2011
Entrez Id: 85358
Gene Symbol: SHANK3
SHANK3
0.300 Biomarker group CTD_human Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. 17173049 2007
Entrez Id: 27328
Gene Symbol: PCDH11X
PCDH11X
0.010 GeneticVariation group BEFREE Recently, a genetic mutation of protocadherin-11X/Y was reported to be associated with a language development disorder. 23527036 2013
Entrez Id: 2077
Gene Symbol: ERF
ERF
0.300 Biomarker group CTD_human Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. 23354439 2013
Entrez Id: 26040
Gene Symbol: SETBP1
SETBP1
0.310 Biomarker group CTD_human Refining analyses of copy number variation identifies specific genes associated with developmental delay. 25217958 2014
Entrez Id: 26040
Gene Symbol: SETBP1
SETBP1
0.310 Biomarker group BEFREE Several genes (including the candidate SETBP1 and other MEF2-related genes) seem to jointly influence certain, but not all, facets of the DLD phenotype. 27016271 2016
Entrez Id: 80031
Gene Symbol: SEMA6D
SEMA6D
0.010 Biomarker group BEFREE The SEMA6D gene was further investigated in samples of individuals with developmental language disorders and controls; this investigation offered further evidence of the involvement of SEMA6D with developmental language disorders. 22266071 2012
Entrez Id: 104355217
Gene Symbol: ERICD
ERICD
0.010 Biomarker group BEFREE This systematic review is undertaken to impose clarity on the nature, extent, and self-regulatory implications of self-directed speech interruption in children with developmental language disorder (DLD), autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD).A rigorous search process of relevant databases (i.e., PsychInfo, PubMed, CINAHL, ERIC) uncovered 19 relevant peer-reviewed articles that investigate self-directed speech in children with neurodevelopmental disorders. 30704545 2020