Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE This study aimed to identify putative functional polymorphisms in the IFNGR1 gene, and to determine whether differences in expression of interferon-γ (IFNG) and IFNGR1 at the RNA level are associated with pathogenesis of VL and/or PKDL in Sudan. 25466928 2014
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Furthermore, stimulation of PBMC isolated from VL patients with rLdcTXN resulted in up-regulation of IL-4 and IL-10 production whereas IL-12 and IFN-γ was significantly down-regulated suggesting a pivotal role of cTXN in provoking the immune suppression during VL. 29554571 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE In the primary domestic reservoir of VL, dogs, we define occurrence of both CD4(+) and CD8(+) T cell exhaustion as a significant stepwise loss of Ag-specific proliferation and IFN-γ production, corresponding to increasing VL symptoms. 24154626 2013
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Clinical trials have shown that protection against VL is associated with robust T cell responses, especially those producing IFN-γ. 29599776 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Treatment of resistant visceral leishmaniasis with interferon gamma in combination with liposomal amphotericin B and allopurinol. 31129197 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The in vitro peptide stimulation of peripheral blood mononuclear cells (PBMC) from cured HLA-A02<sup>+</sup> visceral leishmaniasis (VL) subjects produced significantly higher IFN-γ, IL-2 and IL-12 compared to no peptide control healthy subjects. 28373107 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Immunization with rLdp45 exerted considerable prophylactic efficacy (∼85%) supported by an increase in mRNA expression of iNOS, IFN-γ, TNF-α and IL-12 and decrease in TGF-β and IL-4, indicating its potential as a vaccine candidate against VL. 22502587 2012
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE We performed combined blockade of IFN-γ and TNF-α in VL splenic biopsies and demonstrated it's impact on number of viable amastigotes and cytokine production. 29953494 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE MicroRNA 155 (miR155) promotes CD4<sup>+</sup> Th1 responses and IFN-γ production by targeting suppressor of cytokine signaling-1 (SOCS1) and Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP-1) and therefore could play a role in the resolution of VL. 31182615 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The present findings reinforce the idea that PBMC proliferation and increased IFN-γ production in SLA-stimulated PBMC provide biomarkers of clinical cure in VL. 30483480 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Therapeutic disease CTD_human [Interferon gamma as an immunological strategy for the treatment of human leishmaniasis]. 7854095 1994
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Synergistic effect of interferon-gamma and mannosylated liposome-incorporated doxorubicin in the therapy of experimental visceral leishmaniasis. 10438370 1999
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE In addition, PBMCs collected from treated and untreated mucosal leishmaniasis (ML) and visceral leishmaniasis (VL) patients, as well as in healthy subjects living in endemic region of disease, were in vitro stimulated, when IFN-γ, IL-4 and IL-10 levels were evaluated in the cell supernatant. 31164242 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Most importantly, blockade of IFNγ in ex-vivo splenic aspirate cultures demonstrated that despite the progressive nature of their disease, the endogenous IFNγ produced in patients with active VL serves to limit parasite growth. 25275531 2014
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The stimulation of peripheral blood mononuclear cells with r-LdODC up-regulated IL-10 production but not IFN-γ production from CD4(+) T cells in active as well as cured visceral leishmaniasis cases, indicating a pivotal role for r-LdODC in causing strong immune suppression in a susceptible host. 25449949 2015
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Traditionally, IFN-γ and IL-10 are considered as the two main cytokines which determine the outcome of visceral leishmaniasis. 30175073 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE However, despite expansion of CD4+ T cells and increased IFNγ expression in the spleen, humans with active VL do not control the infection. 28103263 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE This paper examines the IL-2, IFN-γ, IFN-γ-induced protein 10 (IP-10), and monokine-induced-by-IFN-γ (MIG) levels in whole blood-stimulated <i>in vitro</i> with soluble <i>Leishmania</i> antigen (SLA)-taken from asymptomatic individuals and patients treated for VL living in a post-outbreak (<i>Leishmania infantum</i>) area in Spain, and in an endemic (<i>Leishmania donovani</i>) area of Bangladesh. 28620584 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE The protection against VL was associated with increased production of nitric oxide (NO), interferon gamma (IFN-γ), IL-17A, and tumor necrosis factor alpha by splenic cells restimulated <i>ex vivo</i> with <i>L. infantum</i> antigens. 29483288 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE 115 kDa serine protease confers sustained protection to visceral leishmaniasis caused by Leishmania donovani via IFN-γ induced down-regulation of TNF-α mediated MMP-9 activity. 22440312 2013
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE It could be suggested that heritage of AT genotype at position +874 of IFN-γ may predispose and TT genotype can resist individual to VL in an endemic area in the southwest of Iran. 30644801 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE High levels of tumour necrosis factor-alpha (TNF-alpha) and IFN-gamma were present in the sera of HIV-1-infected patients with active VL. 9844050 1998
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Results indicated that the administration of live recombinant Leishmania produced a significant high level of IFN-γ accompanied by reduced levels of IL-10 as compared to wild-type parasites as live vaccine control, thus suggesting the induction of a Th1-type immune response in a mouse model of visceral leishmaniasis. 28426153 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Therapeutic disease CTD_human Tumor necrosis factor (cachectin) in human visceral leishmaniasis. 1901333 1991