Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE As based on their region in the gene, some single nucleotide polymorphisms (SNP) can influence the expression of their corresponding proteins, this study aimed to investigate the association between SNP in the IL-10, IL-12, IFN-γ genes and susceptibility to VL. 30644801 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis. 28626451 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE In comparison with the spleens of the other two patients without visceral leishmaniasis, an increase was observed in the CD4/CD8 ratio and in the number of IL-10- and FoxP3-producing cells, while the number of IL-17-producing cells was lower in the spleen of the patient with visceral leishmaniasis. 25200768 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Deficient CD4(+) T cell effector responses during clinical visceral leishmaniasis (VL) are associated with elevated production of IL-10. 24154626 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE The data implicate IL-10-producing CD25(-)Foxp3(-) T cells in the pathogenesis of human VL. 17389235 2007
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease LHGDN Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis. 17389235 2007
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE The data presented here confirm the results of previous reports that polymorphisms at the -819 position of the IL-10 gene can influence susceptibility to VL suggesting that the C/T genotype may be considered as a risk factor for the disease. 23912644 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE The IL-10 production and Foxp3 expression in peripheral blood mononuclear cells from VL subjects were observed regulated significantly (p = 0.0131 and 0.0436 when compared with untreated samples) in presence of an antagonist to LFA-3. 23974052 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE This specific temporal role for IL-10-mediated susceptibility to VL is of interest. 30017388 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE The stimulation of peripheral blood mononuclear cells with r-LdODC up-regulated IL-10 production but not IFN-γ production from CD4(+) T cells in active as well as cured visceral leishmaniasis cases, indicating a pivotal role for r-LdODC in causing strong immune suppression in a susceptible host. 25449949 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE This was mediated, at least in part, through IFN-γ-induced activation of STAT3 and expression of IL-10, which suggests that splenic macrophages in VL are conditioned to respond to macrophage activation signals with a counter-regulatory response that is ineffective and even disease-promoting. 28141856 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE Furthermore, stimulation of PBMC isolated from VL patients with rLdcTXN resulted in up-regulation of IL-4 and IL-10 production whereas IL-12 and IFN-γ was significantly down-regulated suggesting a pivotal role of cTXN in provoking the immune suppression during VL. 29554571 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Our aim was to assess the value of sCD40L, MMP9 and IL-10 serum levels as signature biomarkers of clinical cure in VL cases from Ethiopia. 27940090 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease CTD_human Heme oxygenase-1 promotes the persistence of Leishmania chagasi infection. 22461696 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease CTD_human To extend testing the therapeutic effects of applying IL-10 receptor (IL-10R) blockade with antileishmanial chemotherapy, BALB/c mice with established intracellular Leishmania donovani infection were injected once with anti-IL-10R mAb at the time low-dose, daily pentavalent antimony (Sb) therapy was initiated. 15716043 2005
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE These results indicate the production of IL-10 during L. donovani infection, and suggest a role for this cytokine in the regulation of immune responsiveness during visceral leishmaniasis. 8326000 1993
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE At VL diagnosis, co-infected patients showed higher serum levels of interferon-gamma (IFN-gamma) than matched HIV-1 controls without VL, and lower serum concentrations of IL-10 than non-immunocompromised VL controls. 9844050 1998
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE mTOR signaling pathway regulates the IL-12/IL-10 axis in Leishmania donovani infection. 21567173 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE Results indicated that the administration of live recombinant Leishmania produced a significant high level of IFN-γ accompanied by reduced levels of IL-10 as compared to wild-type parasites as live vaccine control, thus suggesting the induction of a Th1-type immune response in a mouse model of visceral leishmaniasis. 28426153 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE Monocytes/macrophages of patients with VL demonstrated an increased expression of markers for M(IL-10), along with the absence of markers for M(IL-4). 29745990 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE In addition, PBMCs collected from treated and untreated mucosal leishmaniasis (ML) and visceral leishmaniasis (VL) patients, as well as in healthy subjects living in endemic region of disease, were in vitro stimulated, when IFN-γ, IL-4 and IL-10 levels were evaluated in the cell supernatant. 31164242 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Additionally, most of the peptides, except P2, were found to be non-inducers of CD4+ IL-10 against both active VL as well as treated VL subjects. 29312304 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease CTD_human Circulating immune complexes (IC) and IC-induced levels of GM-CSF are increased in sudanese patients with acute visceral Leishmania donovani infection undergoing sodium stibogluconate treatment: implications for disease pathogenesis. 17404324 2007
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE In contrast, the pathophysiological mechanism of VL has received ample support by the promotion of Th2 cytokines (IL-4 and IL-10) in the presence of arsenic-exposed Leishmania parasites (LdAS). 30721235 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Moreover, the direct evidence of CD4+CD25+FoxP3+ Treg cells as a source of IL-10 and TGFβ during active VL could open new avenues for immunotherapy towards cure of this potentially fatal disease. 26829554 2016