Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE As based on their region in the gene, some single nucleotide polymorphisms (SNP) can influence the expression of their corresponding proteins, this study aimed to investigate the association between SNP in the IL-10, IL-12, IFN-γ genes and susceptibility to VL. 30644801 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE The data presented here confirm the results of previous reports that polymorphisms at the -819 position of the IL-10 gene can influence susceptibility to VL suggesting that the C/T genotype may be considered as a risk factor for the disease. 23912644 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE However, lymphocytes from sVL stimulated with SLA had lower percentages of CD4<sup>+</sup> and CD8<sup>+</sup> cells expressing CD69 and CD8<sup>+</sup> cells expressing CD25, with no release of interferon-γ or tumor necrosis factor. sVL subjects had lower percentage of memory cells (CD4<sup>+</sup> CD45RO+), ex vivo, without SLA stimulation than RecVL, LST+, or LST- (<i>P</i> = 0.0022). 29280433 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE None of the TNF-α alleles and genotypes was associated either to CL or to VL. 25603101 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Analyses showed that the distribution of TNFA RFLP alleles (TNF1 and TNF2) and the TNF MSM alleles (TNFa1 to TNFa15) differed between individuals with VL and those with DTH+ phenotypes. 12438370 2002
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE The protection against VL was associated with increased production of nitric oxide (NO), interferon gamma (IFN-γ), IL-17A, and tumor necrosis factor alpha by splenic cells restimulated <i>ex vivo</i> with <i>L. infantum</i> antigens. 29483288 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE It could be suggested that heritage of AT genotype at position +874 of IFN-γ may predispose and TT genotype can resist individual to VL in an endemic area in the southwest of Iran. 30644801 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE All the exons and exon-intron boundaries of IL10 were sequenced in 184 VL patients along with 172 ethnically matched controls from VL endemic region of India. 25941808 2015
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.370 GeneticVariation disease BEFREE We therefore examined polymorphisms at SLC11A1 in 59 multicase families of VL from the high-incidence Masalit tribe in Sudan. 14523377 2004
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.370 GeneticVariation disease BEFREE This study aimed to determine possible association of SLC11A1 polymorphisms with visceral leishmaniasis among Moroccan children. 25151047 2014
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.370 GeneticVariation disease BEFREE Susceptibility to KA was shown to depend on a locus on chromosomes 22q12 and on NRAMP1 on chromosome 2q35; the data also suggested a third locus in the region 2q23-q24. 17067929 2006
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.370 GeneticVariation disease BEFREE Alleles rs2276631-C (P = 0.02; OR [95%CI] = 2.11 [1.16-3.86]) and rs2279015-G (P = 0.005; OR [95%CI] = 2.42 [1.33-4.41]) of SLC11A1, were associated with susceptibility to VL, whereas genotypes rs2276631 C/C (P = 0.003; OR [95%CI] = 2.65 [1.41-5.00]) and rs2279015 G/G (P = 0.018; OR [95%CI] = 2.05 [1.15-3.64]) were significantly increased in CL and VL patients, respectively. 25603101 2015
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.370 GeneticVariation disease LHGDN Studies have shown that the Nramp1 and H-2 genes are implicated in the control of Leishmania donovani infection in mice. 12618857 2003
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.370 GeneticVariation disease BEFREE No associations were observed between VL and polymorphisms at SLC11A1 that were either robust to correction for multiple testing or replicated across primary and replication samples. 21599885 2011
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.370 GeneticVariation disease BEFREE Our results suggest that polymorphisms in SLC11A1 affect susceptibility to CL and VL. 31230160 2019
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.330 GeneticVariation disease BEFREE Our data provide insight into the molecular mechanisms underpinning the association of HLA-DRB1 alleles with risk versus protection in VL in humans. 29507109 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.330 GeneticVariation disease BEFREE IL-1β (-511T/C) gene polymorphism not IL-1β (+3953T/C) and LT-α (+252A/G) gene variants confers susceptibility to visceral leishmaniasis. 22311026 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.330 GeneticVariation disease BEFREE In conclusion, the HLA-DRB1-HLA-DQA1 HLA class II region contributes to visceral leishmaniasis susceptibility in India and Brazil, suggesting shared genetic risk factors for visceral leishmaniasis that cross the epidemiological divides of geography and parasite species. 23291585 2013
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.310 GeneticVariation disease BEFREE TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis. 21376140 2011
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.310 GeneticVariation disease BEFREE In conclusion, the HLA-DRB1-HLA-DQA1 HLA class II region contributes to visceral leishmaniasis susceptibility in India and Brazil, suggesting shared genetic risk factors for visceral leishmaniasis that cross the epidemiological divides of geography and parasite species. 23291585 2013
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 GeneticVariation disease BEFREE Twenty-three single nucleotide polymorphisms (SNPs) were genotyped in the cytokine 5q23.3-q31.1 region IRF1-IL5-IL13-IL4-IL9-LECT2-TGFBI in 102 families (323 DTH+; 190 DTH-; 123 VL individuals) from a VL endemic region in northeast Brazil. 17713557 2007
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 GeneticVariation disease BEFREE Approximately 70% of the cDNA clones identified by immunoscreening Leishmania donovani expression libraries with serum from a patient with visceral leishmaniasis (kala-azar) were found to encode the highly conserved Hsp90 and Hsp70 members of the heat shock protein family. 1537901 1992
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.050 GeneticVariation disease LHGDN Mannose-binding lectin gene and promoter polymorphism in visceral leishmaniasis caused by Leishmania infantum. 19086549 2007
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.050 GeneticVariation disease BEFREE In conclusion, based on the results, TLR4 gene polymorphisms at the positions 896 and 1196 cannot be regarded as the major contributors to VL susceptibility among the Iranian population. 23053976 2012
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.050 GeneticVariation disease BEFREE This study aimed to investigate possible association of TLR4 Asp299Gly, TLR4 Thr399Ile and TLR2 Arg753Gln polymorphisms with VL in Moroccan children. 26943993 2016