Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.010 Biomarker disease BEFREE Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. 19008139 2009
Entrez Id: 100
Gene Symbol: ADA
ADA
0.010 AlteredExpression disease BEFREE In our previous finding, the level of soluble ADA in serum of visceral leishmaniasis (VL) was found to be increased as compared to healthy controls. 27447233 2016
Entrez Id: 392636
Gene Symbol: AGMO
AGMO
0.010 Biomarker disease BEFREE Exome Sequencing Identifies Two Variants of the Alkylglycerol Monooxygenase Gene as a Cause of Relapses in Visceral Leishmaniasis in Children, in Sudan. 28586473 2017
Entrez Id: 191
Gene Symbol: AHCY
AHCY
0.010 Biomarker disease BEFREE The results indicate the potentiality of rLdAdoHcy protein as a suitable vaccine candidate against VL. 26898994 2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.010 Biomarker disease BEFREE Levels of HDL, LDL fraction, and apolipoprotein A1 in ZVL patients' sera were lower than those of healthy individuals' sera, except for the mean level of VLDL. 29230410 2017
Entrez Id: 358
Gene Symbol: AQP1
AQP1
0.010 GeneticVariation disease BEFREE Cloning and sequencing of the AQP1 gene from both VL and PKDL isolates showed sequence variation in four of the clinical isolates. 20067981 2010
Entrez Id: 9181
Gene Symbol: ARHGEF2
ARHGEF2
0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 339541
Gene Symbol: ARMH1
ARMH1
0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 374569
Gene Symbol: ASPG
ASPG
0.010 Biomarker disease BEFREE Asparaginase, a pivotal enzyme of the aspartate metabolic pathway is present as two variants in Leishmania donovani, causative agent of visceral leishmaniasis (VL). 29551509 2018
Entrez Id: 617
Gene Symbol: BCS1L
BCS1L
0.010 Biomarker disease BEFREE Buparvaquone (BPQ), a hydroxynapthoquinone with in vitro activity in the nanomolar range, failed to clinically translate as a viable treatment for visceral leishmaniasis due to its poor oral bioavailability limited by its poor aqueous solubility (BCS Class II drug). 29762040 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.010 AlteredExpression disease BEFREE Further, the increased levels of TGF-β and caspase 3 at 90th day suggested TGF-β mediated apoptotic cell death of renal and other cells during later stages of disease that may eventually result in release of host and parasitic factors in urine during visceral leishmaniasis. 28606413 2017
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.010 Biomarker disease BEFREE MCP-1 was also significantly elevated in all patients cured of visceral leishmaniasis (VL), unlike IL-2, indicating the specific memory response generated against <i>Leishmania</i>. 29033933 2017
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.020 AlteredExpression disease BEFREE In visceral leishmaniasis (VL), cellular immunosuppression is mediated by impaired DC migration due to the decreased chemokine secretion by endothelium and to the reduced DCs CCR7 expression. 29867949 2018
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.020 AlteredExpression disease BEFREE Further, we found reduced expression of the chemokine receptors CXCR1, CXCR2, CXCR3 and CCR2, but increased expression of CCR7 on VL PBMC, compared to endemic healthy controls. 28222329 2017
Entrez Id: 929
Gene Symbol: CD14
CD14
0.010 AlteredExpression disease BEFREE Active cases of VL was observed with 2.91-fold increased mean florescence intensity (MFI) of LFA-3 expression on CD14(+) cells compared to healthy control (p = 0.0001). 23974052 2013
Entrez Id: 909
Gene Symbol: CD1A
CD1A
0.010 Biomarker disease BEFREE Recent studies have raised the possibility of using immunohistochemistry in the diagnosis of visceral leishmaniasis with labeling of amastigotes by the anti-CD1a antibody. 31017186 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.010 Biomarker disease BEFREE Here, we examined the role of PD1/PDL-1 in the pathogenesis of VL by using a murine model of VL.Our data indicate that <i>L. donovani</i> is able to elicit initial expansion of gamma interferon-producing CD4<sup>+</sup> Th1 and CD8<sup>+</sup> T cells at day 7 postinfection (p.i.); however, the frequency of those cells and inflammatory response decreased at day 21 p.i., despite persistence of parasites. 29610255 2018
Entrez Id: 947
Gene Symbol: CD34
CD34
0.010 Biomarker disease BEFREE In contrast to naïve mice, where most long-term hematopoietic stem cells (LT-HSCs; LSK CD150+ CD34- CD48- cells) in bone marrow (BM) are quiescent, we found that during Leishmania donovani infection most LT-HSCs had entered cell cycle. 28671989 2017
Entrez Id: 958
Gene Symbol: CD40
CD40
0.010 Biomarker disease BEFREE Our results in HIV coinfected patients, correspond with the postulated protective role of sCD40L in VL and underline the importance of the CD40-CD40L pathway in resistance against the parasite. 30619775 2018
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.010 Biomarker disease BEFREE Our results in HIV coinfected patients, correspond with the postulated protective role of sCD40L in VL and underline the importance of the CD40-CD40L pathway in resistance against the parasite. 30619775 2018
Entrez Id: 965
Gene Symbol: CD58
CD58
0.020 Biomarker disease BEFREE The mean florescence intensity (MFI) of CD58 but not of CD2 was twofold higher on CD56<sup>+</sup> cells during VL, but was down-regulated after treatment. 28324803 2017
Entrez Id: 965
Gene Symbol: CD58
CD58
0.020 AlteredExpression disease BEFREE Active cases of VL was observed with 2.91-fold increased mean florescence intensity (MFI) of LFA-3 expression on CD14(+) cells compared to healthy control (p = 0.0001). 23974052 2013
Entrez Id: 969
Gene Symbol: CD69
CD69
0.020 AlteredExpression disease BEFREE The present study has enumerated the effect of 61 kDa recombinant Leishmania donovani co-factor-independent phosphoglycerate mutase (rLd-iPGAM) on mononuclear cells of healthy and treated visceral leishmaniasis subjects as well as on THP-1 cell line. rLd-iPGAM stimulation induced higher expression of interleukin-1β (IL-1β) in the phagocytic cell, its receptor and CD69 on T-cell subsets. 29140228 2018
Entrez Id: 969
Gene Symbol: CD69
CD69
0.020 AlteredExpression disease BEFREE However, lymphocytes from sVL stimulated with SLA had lower percentages of CD4<sup>+</sup> and CD8<sup>+</sup> cells expressing CD69 and CD8<sup>+</sup> cells expressing CD25, with no release of interferon-γ or tumor necrosis factor. sVL subjects had lower percentage of memory cells (CD4<sup>+</sup> CD45RO+), ex vivo, without SLA stimulation than RecVL, LST+, or LST- (<i>P</i> = 0.0022). 29280433 2018
Entrez Id: 51755
Gene Symbol: CDK12
CDK12
0.010 Biomarker disease BEFREE Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis. 30046105 2018