Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 Biomarker disease BEFREE This region, which is the most evolutionarily divergent part of the molecule, was recognized by all sera from patients with visceral leishmaniasis which exhibited an anti-Hsp70 response. 1377180 1992
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 GeneticVariation disease BEFREE Approximately 70% of the cDNA clones identified by immunoscreening Leishmania donovani expression libraries with serum from a patient with visceral leishmaniasis (kala-azar) were found to encode the highly conserved Hsp90 and Hsp70 members of the heat shock protein family. 1537901 1992
Entrez Id: 3320
Gene Symbol: HSP90AA1
HSP90AA1
0.010 Biomarker disease BEFREE Approximately 70% of the cDNA clones identified by immunoscreening Leishmania donovani expression libraries with serum from a patient with visceral leishmaniasis (kala-azar) were found to encode the highly conserved Hsp90 and Hsp70 members of the heat shock protein family. 1537901 1992
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease CTD_human Tumor necrosis factor (cachectin) in human visceral leishmaniasis. 1901333 1991
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Therapeutic disease CTD_human Tumor necrosis factor (cachectin) in human visceral leishmaniasis. 1901333 1991
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.320 Biomarker disease CTD_human Two patients with post-kala-azar dermal leishmaniasis did not have detectable IL-6 in their circulation. 7554475 1995
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Therapeutic disease CTD_human [Interferon gamma as an immunological strategy for the treatment of human leishmaniasis]. 7854095 1994
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.310 Biomarker disease BEFREE Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasis. 7883967 1995
Entrez Id: 89782
Gene Symbol: LMLN
LMLN
0.020 Biomarker disease BEFREE In preliminary trials, rK39 proved superior to 2 purified Leishmania antigens, a cytosolic protein (p36) and a membrane protein (gp63), for immunodiagnosis of visceral leishmaniasis. 7992333 1995
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE Transcript levels of IL-10 as well as IFN-gamma were significantly elevated in patients with active visceral leishmaniasis; IL-10 levels decreased markedly with resolution of disease. 8097208 1993
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.030 Biomarker disease BEFREE Visceral leishmaniasis is associated with a marked depression of T cell responses, which has been characterized by the absence of IL-2 and IFN-gamma production by lymphocytes on in vitro stimulation with Leishmania Ag. 8207220 1994
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE These results indicate the production of IL-10 during L. donovani infection, and suggest a role for this cytokine in the regulation of immune responsiveness during visceral leishmaniasis. 8326000 1993
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 Biomarker disease BEFREE The serological studies conducted with the kala azar positive sera and sera from healthy laboratory workers using the recombinant protein from the E2b clone and having sequence homology to Ldhsp 70, indicated that although all the kala azar sera was positive, 12 of 20 healthy individuals also showed antibodies against the recombinant hsp70, indicating that this antigen is not suitable for serological diagnosis of kala azar. 8595923 1995
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 Biomarker disease BEFREE Mapping of antigenic determinants of the Leishmania infantum Hsp70 was studied by analysis of the reactivity of sera from dogs with natural visceral leishmaniasis against a collection of peptides representing overlapping sequences of the Hsp70. 8905399 1996
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Thus, an aberrant activation of the TNF system with possible negative immunological and virological consequences is present in HIV-1-infected patients with VL. 9844050 1998
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE At VL diagnosis, co-infected patients showed higher serum levels of interferon-gamma (IFN-gamma) than matched HIV-1 controls without VL, and lower serum concentrations of IL-10 than non-immunocompromised VL controls. 9844050 1998
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE High levels of tumour necrosis factor-alpha (TNF-alpha) and IFN-gamma were present in the sera of HIV-1-infected patients with active VL. 9844050 1998
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 Biomarker disease BEFREE Further studies are indicated to determine whether the immunologic detection of IL-4 produced in human visceral leishmaniasis is obscured because of sequestration by soluble receptor and whether the production of sIL-4R is relevant to the pathogenesis of visceral leishmaniasis. 9952391 1999
Entrez Id: 3566
Gene Symbol: IL4R
IL4R
0.020 AlteredExpression disease BEFREE Increased levels of soluble interleukin-4 receptor in the sera of patients with visceral leishmaniasis. 9952391 1999
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Synergistic effect of interferon-gamma and mannosylated liposome-incorporated doxorubicin in the therapy of experimental visceral leishmaniasis. 10438370 1999
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease CTD_human Prognostic value of serum C-reactive protein in kala-azar. 10467834 1999
Entrez Id: 5324
Gene Symbol: PLAG1
PLAG1
0.010 Biomarker disease BEFREE We describe the immune humoral response against the PSA in dogs and human patients with visceral leishmaniasis caused by L. infantum. 10652117 2000
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.010 Biomarker disease BEFREE We describe the immune humoral response against the PSA in dogs and human patients with visceral leishmaniasis caused by L. infantum. 10652117 2000
Entrez Id: 5627
Gene Symbol: PROS1
PROS1
0.010 Biomarker disease BEFREE We describe the immune humoral response against the PSA in dogs and human patients with visceral leishmaniasis caused by L. infantum. 10652117 2000
Entrez Id: 9520
Gene Symbol: NPEPPS
NPEPPS
0.010 Biomarker disease BEFREE We describe the immune humoral response against the PSA in dogs and human patients with visceral leishmaniasis caused by L. infantum. 10652117 2000