Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 GeneticVariation disease BEFREE Approximately 70% of the cDNA clones identified by immunoscreening Leishmania donovani expression libraries with serum from a patient with visceral leishmaniasis (kala-azar) were found to encode the highly conserved Hsp90 and Hsp70 members of the heat shock protein family. 1537901 1992
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 Biomarker disease BEFREE This region, which is the most evolutionarily divergent part of the molecule, was recognized by all sera from patients with visceral leishmaniasis which exhibited an anti-Hsp70 response. 1377180 1992
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 Biomarker disease BEFREE The serological studies conducted with the kala azar positive sera and sera from healthy laboratory workers using the recombinant protein from the E2b clone and having sequence homology to Ldhsp 70, indicated that although all the kala azar sera was positive, 12 of 20 healthy individuals also showed antibodies against the recombinant hsp70, indicating that this antigen is not suitable for serological diagnosis of kala azar. 8595923 1995
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 Biomarker disease BEFREE Mapping of antigenic determinants of the Leishmania infantum Hsp70 was studied by analysis of the reactivity of sera from dogs with natural visceral leishmaniasis against a collection of peptides representing overlapping sequences of the Hsp70. 8905399 1996
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 Biomarker disease BEFREE In the present study, Restriction Fragment Length Polymorphism (RFLP) of three genetic markers viz., Internal Transcribed Spacer (ITS), ITS1 and heat shock protein 70 (hsp70) have been employed for typing the clinical isolates [n=15] of KA and post Kala-azar Dermal Leishmaniosis (PKDL) collected from India and Bangladesh in the period of 2006-2010. 22960646 2012
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.060 Biomarker disease BEFREE The sensitivities of PCR targets except ITS1-PCR, ME-PCR and HSP70-PCR were found to be 100% in cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) cases as compared to microscopic examination accepted as a gold standard. 26896641 2016