Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.050 Biomarker disease BEFREE We optimized and assessed in vivo the safety and immunogenicity of an innovative vaccine candidate against human visceral leishmaniasis (VL), consisting of Virus-Like Particles (VLP) loaded with three different recombinant proteins (LJL143 from Lutzomyia longipalpis saliva as the vector-derived (VD) component, and KMP11 and LeishF3+, as parasite-derived (PD) antigens) and adjuvanted with GLA-SE, a TLR4 agonist. 29176865 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.050 GeneticVariation disease BEFREE This study aimed to investigate possible association of TLR4 Asp299Gly, TLR4 Thr399Ile and TLR2 Arg753Gln polymorphisms with VL in Moroccan children. 26943993 2016
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.050 AlteredExpression disease BEFREE TLR4 and TLR9 were found to be highly expressed in patients with VL. 25982946 2015
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.050 GeneticVariation disease BEFREE In conclusion, based on the results, TLR4 gene polymorphisms at the positions 896 and 1196 cannot be regarded as the major contributors to VL susceptibility among the Iranian population. 23053976 2012
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.050 Biomarker disease BEFREE Miltefosine triggers a strong proinflammatory cytokine response during visceral leishmaniasis: role of TLR4 and TLR9. 22361489 2012