Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Efficacy against VL was mediated by a CD4<sup>+</sup>TNF-α T lymphocyte response against the NH36-F3 domain, while against tegumentary leishmaniasis (TL) a CD8<sup>+</sup> T lymphocyte response to F1 was also required. 31040850 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE The protection against VL was associated with increased production of nitric oxide (NO), interferon gamma (IFN-γ), IL-17A, and tumor necrosis factor alpha by splenic cells restimulated <i>ex vivo</i> with <i>L. infantum</i> antigens. 29483288 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE However, lymphocytes from sVL stimulated with SLA had lower percentages of CD4<sup>+</sup> and CD8<sup>+</sup> cells expressing CD69 and CD8<sup>+</sup> cells expressing CD25, with no release of interferon-γ or tumor necrosis factor. sVL subjects had lower percentage of memory cells (CD4<sup>+</sup> CD45RO+), ex vivo, without SLA stimulation than RecVL, LST+, or LST- (<i>P</i> = 0.0022). 29280433 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE We performed combined blockade of IFN-γ and TNF-α in VL splenic biopsies and demonstrated it's impact on number of viable amastigotes and cytokine production. 29953494 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Sera from Visceral Leishmaniasis Patients Display Oxidative Activity and Affect the TNF-<i>α</i> Production by Macrophages <i>In Vitro</i>. 29230410 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Leptin-induced IFN-γ, IL-2, and TNF-α cytokines in the culture supernatant of splenocytes upon soluble leishmanial antigen (SLA) stimulation and significantly up-regulates serum IgG2a titers, which help to generate Th1 immune response in VL. 29116252 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE None of the TNF-α alleles and genotypes was associated either to CL or to VL. 25603101 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Visceral leishmaniasis (VL) is associated with increased circulating levels of multiple pro-inflammatory cytokines and chemokines, including IL-12, IFNγ, and TNFα, and elevated expression of IFNγ mRNA in lesional tissue such as the spleen and bone marrow. 25275531 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease CTD_human Heme oxygenase-1 promotes the persistence of Leishmania chagasi infection. 22461696 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Immunization with rLdp45 exerted considerable prophylactic efficacy (∼85%) supported by an increase in mRNA expression of iNOS, IFN-γ, TNF-α and IL-12 and decrease in TGF-β and IL-4, indicating its potential as a vaccine candidate against VL. 22502587 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Analyses showed that the distribution of TNFA RFLP alleles (TNF1 and TNF2) and the TNF MSM alleles (TNFa1 to TNFa15) differed between individuals with VL and those with DTH+ phenotypes. 12438370 2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Thus, an aberrant activation of the TNF system with possible negative immunological and virological consequences is present in HIV-1-infected patients with VL. 9844050 1998
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease CTD_human Tumor necrosis factor (cachectin) in human visceral leishmaniasis. 1901333 1991