Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation disease BEFREE As based on their region in the gene, some single nucleotide polymorphisms (SNP) can influence the expression of their corresponding proteins, this study aimed to investigate the association between SNP in the IL-10, IL-12, IFN-γ genes and susceptibility to VL. 30644801 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Treatment of resistant visceral leishmaniasis with interferon gamma in combination with liposomal amphotericin B and allopurinol. 31129197 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE MicroRNA 155 (miR155) promotes CD4<sup>+</sup> Th1 responses and IFN-γ production by targeting suppressor of cytokine signaling-1 (SOCS1) and Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP-1) and therefore could play a role in the resolution of VL. 31182615 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE In addition, PBMCs collected from treated and untreated mucosal leishmaniasis (ML) and visceral leishmaniasis (VL) patients, as well as in healthy subjects living in endemic region of disease, were in vitro stimulated, when IFN-γ, IL-4 and IL-10 levels were evaluated in the cell supernatant. 31164242 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Efficacy against VL was mediated by a CD4<sup>+</sup>TNF-α T lymphocyte response against the NH36-F3 domain, while against tegumentary leishmaniasis (TL) a CD8<sup>+</sup> T lymphocyte response to F1 was also required. 31040850 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE In addition, PBMCs collected from treated and untreated mucosal leishmaniasis (ML) and visceral leishmaniasis (VL) patients, as well as in healthy subjects living in endemic region of disease, were in vitro stimulated, when IFN-γ, IL-4 and IL-10 levels were evaluated in the cell supernatant. 31164242 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE It could be suggested that heritage of AT genotype at position +874 of IFN-γ may predispose and TT genotype can resist individual to VL in an endemic area in the southwest of Iran. 30644801 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE In contrast, the pathophysiological mechanism of VL has received ample support by the promotion of Th2 cytokines (IL-4 and IL-10) in the presence of arsenic-exposed Leishmania parasites (LdAS). 30721235 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Furthermore, stimulation of PBMC isolated from VL patients with rLdcTXN resulted in up-regulation of IL-4 and IL-10 production whereas IL-12 and IFN-γ was significantly down-regulated suggesting a pivotal role of cTXN in provoking the immune suppression during VL. 29554571 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Clinical trials have shown that protection against VL is associated with robust T cell responses, especially those producing IFN-γ. 29599776 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE We performed combined blockade of IFN-γ and TNF-α in VL splenic biopsies and demonstrated it's impact on number of viable amastigotes and cytokine production. 29953494 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE This specific temporal role for IL-10-mediated susceptibility to VL is of interest. 30017388 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The present findings reinforce the idea that PBMC proliferation and increased IFN-γ production in SLA-stimulated PBMC provide biomarkers of clinical cure in VL. 30483480 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE The protection against VL was associated with increased production of nitric oxide (NO), interferon gamma (IFN-γ), IL-17A, and tumor necrosis factor alpha by splenic cells restimulated <i>ex vivo</i> with <i>L. infantum</i> antigens. 29483288 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE However, lymphocytes from sVL stimulated with SLA had lower percentages of CD4<sup>+</sup> and CD8<sup>+</sup> cells expressing CD69 and CD8<sup>+</sup> cells expressing CD25, with no release of interferon-γ or tumor necrosis factor. sVL subjects had lower percentage of memory cells (CD4<sup>+</sup> CD45RO+), ex vivo, without SLA stimulation than RecVL, LST+, or LST- (<i>P</i> = 0.0022). 29280433 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE Furthermore, stimulation of PBMC isolated from VL patients with rLdcTXN resulted in up-regulation of IL-4 and IL-10 production whereas IL-12 and IFN-γ was significantly down-regulated suggesting a pivotal role of cTXN in provoking the immune suppression during VL. 29554571 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE We performed combined blockade of IFN-γ and TNF-α in VL splenic biopsies and demonstrated it's impact on number of viable amastigotes and cytokine production. 29953494 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Traditionally, IFN-γ and IL-10 are considered as the two main cytokines which determine the outcome of visceral leishmaniasis. 30175073 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE Monocytes/macrophages of patients with VL demonstrated an increased expression of markers for M(IL-10), along with the absence of markers for M(IL-4). 29745990 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE The protection against VL was associated with increased production of nitric oxide (NO), interferon gamma (IFN-γ), IL-17A, and tumor necrosis factor alpha by splenic cells restimulated <i>ex vivo</i> with <i>L. infantum</i> antigens. 29483288 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Traditionally, IFN-γ and IL-10 are considered as the two main cytokines which determine the outcome of visceral leishmaniasis. 30175073 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis. 28626451 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The in vitro peptide stimulation of peripheral blood mononuclear cells (PBMC) from cured HLA-A02<sup>+</sup> visceral leishmaniasis (VL) subjects produced significantly higher IFN-γ, IL-2 and IL-12 compared to no peptide control healthy subjects. 28373107 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 AlteredExpression disease BEFREE This was mediated, at least in part, through IFN-γ-induced activation of STAT3 and expression of IL-10, which suggests that splenic macrophages in VL are conditioned to respond to macrophage activation signals with a counter-regulatory response that is ineffective and even disease-promoting. 28141856 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 Biomarker disease BEFREE Our aim was to assess the value of sCD40L, MMP9 and IL-10 serum levels as signature biomarkers of clinical cure in VL cases from Ethiopia. 27940090 2017