|
HLA-DRB1
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
|
25642632 |
2015 |
|
HLA-DRB1
|
0.190 |
Biomarker
|
disease |
BEFREE |
The frequency of HLA-DRB1* alleles between the control group and leprosy patient subgroups presenting different forms of the disease showed that the HLA-DRB1*16 (16.13% vs. 8.24%, OR = 4.10, CI = 1.27-13.27, p = 0.010) and HLA-DRB1*14 (5% vs. 3.53%, OR = 4.63, CI = 1.00-21.08, p = 0.032) alleles were significantly more frequent in patients with different clinical subtypes of leprosy.
|
23283466 |
2012 |
|
HLA-DRB1
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0.31, 95% CI = 0.20-0.48, and HLA-DQA1 rs1071630, case-control P = 4.9 x 10(-14), OR = 0.43, 95% CI = 0.35-0.54).
|
20617178 |
2010 |
|
HLA-DRB1
|
0.190 |
Biomarker
|
disease |
BEFREE |
These data confirm the positive association of HLA-DR2 (DRB1*16) with leprosy per se, and the protector effect of DRB1*04 against lepromatous leprosy in Brazilian patients.
|
19698125 |
2009 |
|
HLA-DRB1
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Genomewide association study of leprosy.
|
20018961 |
2009 |
|
HLA-DRB1
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population.
|
20003324 |
2009 |
|
HLA-DRB1
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Genomewide association study of leprosy.
|
20018961 |
2009 |
|
HLA-DRB1
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DRB1 alleles could act alone or in combination with other genes to confer differential susceptibility and also protection to leprosy disease in endemic areas of the American continent.
|
18275683 |
2008 |
|
HLA-DRB1
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
In this work, we analyzed the influence of the HLA-DRB1 locus on leprosy susceptibility per se and disease type using a case-control design carried out in Brazilians (578 cases and 691 controls) and a replication study based on a family design in a Vietnamese population (n=194 families).
|
17396103 |
2007 |
|
HLA-DRB1
|
0.190 |
Biomarker
|
disease |
BEFREE |
The associations with MICA and MICB cannot be accounted for by linkage disequilibrium with the HLA class II locus indicating a role in genetic susceptibility to leprosy that is independent of HLA-DRB1.
|
16923796 |
2006 |
|
HLA-DRB1
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
The resulting response translates to various forms of leprosy depending on degree of charge consonance between M. leprae and host DRB1 allele.
|
10540160 |
1999 |
|
HLA-DRB1
|
0.190 |
Biomarker
|
disease |
BEFREE |
The much stronger association of DRB1*1501 with the multibacillary form than with the TT type of leprosy suggests a possible role in the differential immune response to M. leprae antigens.
|
8284786 |
1993 |