Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 283234
Gene Symbol: CCDC88B
CCDC88B
0.410 Biomarker disease CTD_human Besides confirming all previously published loci, we discovered six new susceptibility loci, and further gene prioritization analysis of these loci implicated BATF3, CCDC88B and CIITA-SOCS1 as new susceptibility genes for leprosy. 25642632 2015
Entrez Id: 283234
Gene Symbol: CCDC88B
CCDC88B
0.410 Biomarker disease BEFREE Besides confirming all previously published loci, we discovered six new susceptibility loci, and further gene prioritization analysis of these loci implicated BATF3, CCDC88B and CIITA-SOCS1 as new susceptibility genes for leprosy. 25642632 2015
Entrez Id: 283234
Gene Symbol: CCDC88B
CCDC88B
0.410 GeneticVariation disease GWASCAT Besides confirming all previously published loci, we discovered six new susceptibility loci, and further gene prioritization analysis of these loci implicated BATF3, CCDC88B and CIITA-SOCS1 as new susceptibility genes for leprosy. 25642632 2015
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 GeneticVariation disease BEFREE Polymorphisms in the human Slc11a1/Nramp1 gene have been associated with host susceptibility to leprosy. 26814595 2016
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 GeneticVariation disease BEFREE Genetic factors, such as the vitamin D receptor, the major histocompatibility complex region, chromosome 20, human toll-like receptors, the natural resistance-associated macrophage protein 1, the nucleotide-binding oligomerization domain containing 2, phosphate-regulating gene with homologies to endopeptidase on the X chromosome and the tyrosine kinase growth factor receptor-ErbB-2, contribute to both vitamin D status and leprosy. 22170299 2012
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 Biomarker disease CTD_human Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV. 16597321 2006
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 GeneticVariation disease BEFREE Thus, variation in or near the NRAMP1 gene may exert an influence on the clinical presentation of leprosy, possibly by influencing cellular immune response type. 11791966 2001
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 GeneticVariation disease BEFREE In the homologous human NRAMP1 gene, a total of 11 polymorphisms have been identified, which are being used to test for the linkage of NRAMP1 alleles with human responses to mycobacteria, including susceptibility to tuberculosis and leprosy, as well as BCG immunotherapy in bladder cancer. 11010829 2000
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 GeneticVariation disease BEFREE A sib-pair linkage analysis between the Mitsuda response and the NRAMP1 gene was done among 20 nuclear families with leprosy (totaling 118 sibs) from Ho Chi Minh City, Vietnam. 10608779 2000
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 Biomarker disease BEFREE Several studies now provide evidence for a role for NRAMP1 in determining human susceptibility to autoimmune (rheumatoid arthritis. juvenile rheumatoid arthritis, diabetes, Crohn's disease) and infectious (tuberculosis, leprosy) diseases.Amongst these. data are accumulating to support the hypothesis that a functional Z-DNA forming repeat polymorphism in the promoter region of human NRAMP1 contributes directly to disease susceptibility. 10065630 1999
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 GeneticVariation disease BEFREE This finding is consistent with the hypothesis that NRAMP1 itself is a leprosy susceptibility locus. 9419180 1998
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 GeneticVariation disease BEFREE Through comparative genomics, we have identified the homologous human NRAMP1 gene, alleles of which are now being used for tests of linkage with TB and leprosy. 9509263 1998
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
0.390 GeneticVariation disease BEFREE Recent genetic studies have found that allelic variants at the human NRAMP1 locus are associated with susceptibility to leprosy (Mycobacterium leprae) and tuberculosis (Mycobacterium tuberculosis) and possibly with the onset of rheumatoid arthritis. 9719491 1998
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.380 AlteredExpression disease BEFREE The high TLR2 expression associated with IL-10 levels, in the leprosy reaction groups, may be hypothetically related to the formation of TLR2/2 homodimers and/or TLR2/6 heterodimers linked to evasion mechanisms in downgrading reactions and pathophysiology of ENL. 31781675 2019
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.380 GeneticVariation disease BEFREE Our results show an association between the T allele of rs3804099 at the TLR2 gene and increased risk for leprosy per se [Odds ratio (OR) = 1.296, p = 0,022]. 28327786 2017
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.380 GeneticVariation disease BEFREE High IL10 producing allele of TLR2 microsatellite might predispose house hold contacts to leprosy. 23619473 2013
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.380 Biomarker disease BEFREE The data support the possibility of an important role for TLR2 and TLR4 in the pathogenesis of this important complication of leprosy. 22348338 2012
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.380 GeneticVariation disease BEFREE The goal of the present study was to assess the effect of Toll-like receptor 2 (TLR2) polymorphisms on susceptibility to and clinical presentation of leprosy. 18177245 2008
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.380 GeneticVariation disease BEFREE TLR2 Arg677Trp polymorphism in leprosy: revisited. 15726416 2005
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.380 GeneticVariation disease BEFREE Polymorphisms of TLR2 (which recognizes mycobacterial components in concert with CD14) are involved in the pattern of response to mycobacteria, and in the type of leprosy that develops. 14501431 2003
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.380 Biomarker disease BEFREE Here, the events triggered by TLR2 in response to cell lysate of Mycobacterium leprae(MLL), the causative agent of leprosy, were investigated. 12445799 2002
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.380 Biomarker disease CTD_human
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
0.370 GeneticVariation disease BEFREE Our findings suggest that the TLR1 polymorphism was associated with an increased protection from leprosy in women. 30289892 2018
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
0.370 GeneticVariation disease BEFREE To evaluate the role of polymorphisms in genes TLR1, TLR2 and TLR4 and susceptibility to leprosy in a genetic case control study; to verify the association between genotypes of these markers and the immunological profile in the serum of patients with leprosy. 28327786 2017
Entrez Id: 7096
Gene Symbol: TLR1
TLR1
0.370 Biomarker disease BEFREE Our results suggest that TLR1 248S is associated with an increased risk for leprosy, consistent with its hypoimmune regulatory function. 23547143 2013