Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease BEFREE Our results confirm that BRAF V600E-positive HCL is a relatively rare disorder in the Japanese leukemia patient population. 30043333 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease BEFREE Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias. 24433452 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease BEFREE Characterization of a patient with concurrent BRAF-mutant melanoma and NRAS-mutant leukemia treated intermittently with combined BRAF and MEK inhibition provides new insights into the potential clinical and molecular effects of this therapeutic strategy. 24795008 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease BEFREE These data support testing of intermittent ERK pathway inhibition in the therapy for both RAS-mutant leukemia and BRAF-mutant melanoma. 24589925 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease BEFREE The BRAF kinase is mutated, typically Val 600→Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a smaller extent, a wide spectrum of other cancers. 24717435 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease BEFREE The ERK1/2 (extracellular signal-regulated kinase 1 and 2) pathway, comprising the protein kinases RAF (v-raf-1 murine leukemia viral oncogene homolog 1), MEK1/2 (mitogen-activated protein kinase or ERK kinase 1 and 2) and ERK1/2 is frequently de-regulated in human cancers, due to mutations in RAS or BRAF (v-raf-1 murine leukemia viral oncogene homolog B1). 22562245 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease BEFREE None of the 195 patients with other peripheral B-cell lymphomas or leukemias who were evaluated carried the BRAF V600E variant, including 38 patients with splenic marginal-zone lymphomas or unclassifiable splenic lymphomas or leukemias. 21663470 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease CLINVAR Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. 19206169 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease CLINVAR Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome. 18042262 2008
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease BEFREE Leukemia in Cardio-facio-cutaneous (CFC) syndrome: a patient with a germline mutation in BRAF proto-oncogene. 17483702 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 GeneticVariation disease CLINVAR Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 AlteredExpression disease BEFREE Expression and activation of B-Raf kinase isoforms in human and murine leukemia cell lines. 7535416 1995
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.490 Biomarker disease GENOMICS_ENGLAND