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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chronic lymphocytic leukemia (CLL) is unique among B cell malignancies in that the malignant clones can be featured either somatically mutated or unmutated IGVH genes.
|
22526361 |
2012 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A higher TCL1 expression level was detected in patients with CLL with unmutated vs. mutated IGHV genes (P < 0.001), whereas no difference was demonstrated within the IGHV3-21 cohort (i.e., mutated vs. unmutated and stereotyped vs. non-stereotyped complementarity determining region 3).
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19889012 |
2010 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have extensively characterized the DNA methylomes of 139 patients with chronic lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell subpopulations through the use of whole-genome bisulfite sequencing and high-density microarrays.
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23064414 |
2012 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, using ChIP-sequencing, we identified EZH2 and H3K27me3 target genes in two prognostic subgroups of CLL with distinct prognosis and outcome, i.e., cases with unmutated (U-CLL, n = 6) or mutated IGHV genes (M-CLL, n = 6).
|
31216925 |
2019 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IGHV mutation status-which distinguishes the two major subtypes of CLL-was accurately predicted by the chromatin profiles and gene regulatory networks inferred for IGHV-mutated versus IGHV-unmutated samples identified characteristic differences between these two disease subtypes.
|
27346425 |
2016 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The second group included 19 cases, mostly diagnosed as B-cell chronic lymphocytic leukemia (B-CLL), and characterized by few additional chromosomal changes (e.g. trisomy 12) and unmutated IgVH genes.
|
17495977 |
2007 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, although not clearly related to clinical staging or other prognostic factors including IGHV mutational status and CD38 expression, strong KLK14 mRNA expression was shown to predict reduced overall survival of CLL patients (p=0.026) using Kaplan-Meier survival analysis.
|
26351937 |
2016 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Bone marrow infiltration pattern in B-cell chronic lymphocytic leukemia is related to immunoglobulin heavy-chain variable region mutation status and expression of 70-kd zeta-associated protein (ZAP-70).
|
16938520 |
2006 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CLL cases can be divided in two subgroups with different clinical course based on the mutational status of the immunoglobulin heavy variable (IGHV) genes: mutated CLL (M-CLL) and unmutated CLL (U-CLL).
|
31108207 |
2019 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relevant observations have been made in chronic lymphocytic leukemia (CLL), where gene mutations are distributed asymmetrically in cases bearing or not somatic hypermutations within the clonotypic immunoglobulin heavy chain variable region (IGHV) genes (e.g.
|
28892161 |
2017 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The immunoglobulin variable heavy chain (IgVH) gene mutation status is an important prognostic factor in chronic lymphocytic leukemia (CLL), since cases with mutated VH genes show significantly longer survival than unmutated cases.
|
12586612 |
2003 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Methylation markers identify high risk patients in IGHV mutated chronic lymphocytic leukemia.
|
21051931 |
2011 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the t(14;18) in chronic lymphocytic leukemia is associated with relatively young age at diagnosis, mutated immunoglobulin heavy chain variable region genes, and a clinical course that usually requires chemotherapy.
|
23084581 |
2013 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CTRAs were assigned to two categories (i) CTRAs present in the context of KC, often with involvement of chromosome 17p aberrations, occurring mostly in CLL with unmutated IGHV genes; in such cases, we found that KC rather than the presence of CTRAs per se negatively impacts on survival; (ii) CTRAs in cases without KC, having limited if any impact on survival.
|
24166834 |
2014 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasma TPO and beta2-M may be useful for the prediction of clinical behavior in CLL and may replace the need for the determination of IgV(H) mutation status.
|
16551975 |
2006 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal aberrations, IGHV and TP53 mutation status are well-established and essential to discriminate between a more indolent course of disease and a high-risk CLL, which requires an alternative treatment regimen.
|
26890126 |
2016 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, the methylation pattern correlated with the major biological (ZAP-70 and CD38), and molecular (IGHV mutation) markers, distinguishing CLL cases according to IGHV mutational status.
|
24347044 |
2014 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, high binding to MEACs significantly correlated with poor patient survival, suggesting that the basis of IGHV mutation status as a CLL prognostic factor reflects antigen binding.
|
20110421 |
2010 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In chronic lymphocytic leukaemia (CLL), the somatic hypermutation (SHM) status of the clonotypic rearranged IGHV gene is strongly associated with patient outcome.
|
25388851 |
2015 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinical data and immunoglobulin variable heavy chain (IgVH) gene configuration were analyzed in 47 CLL patients, exposed to ionizing radiation (IR) due to Chernobyl NPP accident, and 141 non-exposed patients.
|
17897714 |
2008 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evidence for immunoglobulin heavy chain variable region gene replacement in a patient with B cell chronic lymphocytic leukemia.
|
8751479 |
1996 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The outcome of Chronic lymphocytic leukaemia patients with 97% IGHV gene identity to germline is distinct from cases with <97% identity and similar to those with 98% identity.
|
26846718 |
2016 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The immunoglobulin heavy chain variable (IGHV) gene mutational status represents a major prognostic marker in chronic lymphocytic leukemia (CLL).
|
23450508 |
2013 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of an IGHV gene somatic mutation and the utilization of a skewed gene repertoire compared with normal B cells together with the expression of stereotyped receptors by unmutated CLL clones may indicate stimulation/selection by antigenic epitopes.
|
21541442 |
2011 |
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LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we retrospectively studied 595 Chinese CLL patients to determine the best cutoff value for IGHV in Chinese CLL population.
|
31849198 |
2020 |