Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE The past decade has witnessed tremendous progress in the treatment of acute lymphoblastic leukaemia (ALL), primarily due to the development of targeted therapies, including tyrosine kinase inhibitors targeting BCR-ABL1 tyrosine kinase, monoclonal antibodies targeting cell surface antigens (CD19, CD20 and CD22), bispecific antibodies and chimeric antigen receptor T- cell therapy. 31566728 2020
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE There have been successful examples of targeted therapy improving the outcome of some childhood cancers, such as the addition of an ABL class tyrosine kinase inhibitor to conventional chemotherapy substantially improving the cure rate for patients with BCR-ABL1 positive acute lymphoblastic leukemia. 31563145 2020
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE The ETV6-ABL1 fusion is a rare genetic aberration classified as Philadelphia chromosome-like high-risk B-cell precursor acute lymphoblastic leukemia. 30028819 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. 31296070 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE We searched for original articles and reviews describing the pharmacology and clinical use of dasatinib in ALL with BCR-ABL1. 30916583 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia. 30546081 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE There are different BCR-ABL1 fusion genes that are translated into proteins that are different from each other, yet all leukemogenic, causing chronic myeloid leukemia (CML) or acute lymphoblastic leukemia. 30675008 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Our B-ALL fluorescence in situ hybridization (FISH) panel confirmed the BCR/ABL1 fusion and monosomies consistent with chromosome studies in approximately 95% of interphase nuclei. 30790375 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE BCR-ABL1 signal patterns were analyzed using FISH in 243 CML-chronic phase (CML-CP), 17 CML-blast phase (CML-BP) and 52 BCR-ABL1 positive acute lymphoblastic leukemia (ALL) patients. 31594548 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE At current work, the combination of sensors were used to detect the presence of BCR-ABL1 as a mutant gene and CEA as a biomarkers of cancer, such a capability makes the package liable for early and certain detection of acute lymphoblastic leukemia. 31295447 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Four patients presented with B-lymphoblastic leukemia (B-ALL), and of them, two patients with t(8;9)(p22;p24.1) were proven to be B-lymphoblastic crisis of MPN; and the other two cases with t(9p24;v) both were de novo B-ALL, BCR-ABL1-like (Ph-like). 30401948 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 AlteredExpression disease BEFREE We here describe the first results by the EURO-MRD consortium on standardization of qRT-PCR for the e1a2 BCR-ABL1 transcript in Ph + ALL, designed to overcome the lack of standardisation of laboratory procedures and data interpretation. 30858550 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE The Philadelphia chromosome is found in 30% of acute lymphoblastic leukemia (ALL) patients, a distinct ALL subgroup where the BCR-ABL fusion gene is associated with poor prognosis. 30591491 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis. 31173268 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 AlteredExpression disease BEFREE In the present study, OX40 expression on ALL cells was significantly associated with positivity for the adverse risk factor BCR-ABL. 30300827 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Phosphatase of regenerating liver-3 <i>(PRL-3/PTP4A3)</i> is upregulated in multiple cancers, including BCR-ABL1- and ETV6-RUNX-positive acute lymphoblastic leukemia (ALL). 29423065 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE A Cryptic NUP214-ABL1 Fusion in B-cell Precursor Acute Lymphoblastic Leukemia. 29219890 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE To our knowledge, this is the first successful use of nilotinib in BCR-ABL1-like phenotype ALL. 30121665 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 AlteredExpression disease BEFREE Chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) are hematopoietic malignancies caused by the constitutive activation of BCR-ABL tyrosine kinase. 29859988 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 AlteredExpression disease BEFREE A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy. 29434963 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE This case illustrates the major interest of interphase FISH for BCR-ABL1 rearrangement on blood neutrophils as a decisive method to discriminate a lymphoid blast crisis of CML from a de novo BCR-ABL1 positive ALL. 28444777 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Two novel fusion genes, AIF1L-ETV6 and ABL1-AIF1L, result together with ETV6-ABL1 from a single chromosomal rearrangement in acute lymphoblastic leukemia with prenatal origin. 29726059 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE BCR/ABL1-like acute lymphoblastic leukaemia (ALL) is a subgroup of B-lineage acute lymphoblastic leukaemia that occurs within cases without recurrent molecular rearrangements. 29675955 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE To address this, we studied 142 adults with ALL treated with hyperCVAD over a 10-year period who had MRD assessed by either multi-parameter flow cytometry or (for patients with Philadelphia chromosome positive ALL) reverse transcriptase polymerase chain reaction for the BCR-ABL1 translocation. 29318644 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE ETV6-ABL1 fusion combined with monosomy 7 in childhood B-precursor acute lymphoblastic leukemia. 29177615 2018