Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The past decade has witnessed tremendous progress in the treatment of acute lymphoblastic leukaemia (ALL), primarily due to the development of targeted therapies, including tyrosine kinase inhibitors targeting BCR-ABL1 tyrosine kinase, monoclonal antibodies targeting cell surface antigens (CD19, CD20 and CD22), bispecific antibodies and chimeric antigen receptor T- cell therapy. 31566728 2020
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE There have been successful examples of targeted therapy improving the outcome of some childhood cancers, such as the addition of an ABL class tyrosine kinase inhibitor to conventional chemotherapy substantially improving the cure rate for patients with BCR-ABL1 positive acute lymphoblastic leukemia. 31563145 2020
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Of the total 631 cases, 52.9% (n=334) were acute lymphoblastic leukemia (ALL), 43.9% (n=277) acute myeloid leukemia (AML), 2.2% (n=14) mixed phenotypic acute leukemia (MPAL), 0.5% (n=3) acute undifferentiated leukemia (AUL) and 0.5% (n=3) chronic myeloid leukemia in blast crisis (CML-BC). 30858955 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE There are different BCR-ABL1 fusion genes that are translated into proteins that are different from each other, yet all leukemogenic, causing chronic myeloid leukemia (CML) or acute lymphoblastic leukemia. 30675008 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Molecular detection of the <i>BCR-ABL1</i> fusion transcripts is necessary for the genetic confirmation of a chronic myeloid leukemia diagnosis and for the risk classification of acute lymphoblastic leukemia. 31817063 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE At the 60<sup>th</sup> month, estimated CBMR and CEMR incidences were, respectively, 14.3 (5.1)% and 25.9 (6.6)% in ALL, 25.8 (5.9)% and 15.5 (4.8)% in AML, and 61.5 (16.5)% and 17.9 (13.4)% in CML. 30116013 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE We searched for original articles and reviews describing the pharmacology and clinical use of dasatinib in ALL with BCR-ABL1. 30916583 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE At current work, the combination of sensors were used to detect the presence of BCR-ABL1 as a mutant gene and CEA as a biomarkers of cancer, such a capability makes the package liable for early and certain detection of acute lymphoblastic leukemia. 31295447 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis. 31173268 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE BCR-ABL1 signal patterns were analyzed using FISH in 243 CML-chronic phase (CML-CP), 17 CML-blast phase (CML-BP) and 52 BCR-ABL1 positive acute lymphoblastic leukemia (ALL) patients. 31594548 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Four patients presented with B-lymphoblastic leukemia (B-ALL), and of them, two patients with t(8;9)(p22;p24.1) were proven to be B-lymphoblastic crisis of MPN; and the other two cases with t(9p24;v) both were de novo B-ALL, BCR-ABL1-like (Ph-like). 30401948 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE An 11-year-old male patient with the deletion of <i>IKZF1</i> (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(<i>BCR-ABL1</i>) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate. 31607921 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE To date, no case reports of a patient diagnosed with CML BC presented with Ph chromosome-positive AML mimicking ALL have been reported. 31218758 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Our B-ALL fluorescence in situ hybridization (FISH) panel confirmed the BCR/ABL1 fusion and monosomies consistent with chromosome studies in approximately 95% of interphase nuclei. 30790375 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE This case illustrates the major interest of interphase FISH for BCR-ABL1 rearrangement on blood neutrophils as a decisive method to discriminate a lymphoid blast crisis of CML from a de novo BCR-ABL1 positive ALL. 28444777 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Pediatric ALL had higher prevalence of ETV6-RUNX1, TCF3-PBX1, and STIL-TAL1, while BCR-ABL1 and SET-NUP214 were more common in adult ALL. 30125757 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE BCR/ABL1-like acute lymphoblastic leukaemia (ALL) is a subgroup of B-lineage acute lymphoblastic leukaemia that occurs within cases without recurrent molecular rearrangements. 29675955 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia. 28579617 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE CD25 (IL-2RA) and CD26 (DPPIV) were expressed on LSCs in Ph<sup>+</sup> ALL exhibiting BCR/ABL1<sub>p210</sub>, whereas in Ph<sup>+</sup> ALL with BCR/ABL1<sub>p190</sub>, LSCs variably expressed CD25 but did not express CD26. 29772458 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE E14a3 breakpoint cluster region (BCR)/ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL) fusion transcript is rare in Philadelphia chromosome positive disease, particularly in acute lymphoblastic leukemia (ALL). 29434963 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE <i>IKZF1</i> gene defects are associated with inferior treatment outcome in both childhood and adult B-cell precursor acute lymphoblastic leukemia and occur in more than 70% of <i>BCR-ABL1</i>-positive and <i>BCR-ABL1</i>-like cases of acute lymphoblastic leukemia. 29519871 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Phosphatase of regenerating liver-3 <i>(PRL-3/PTP4A3)</i> is upregulated in multiple cancers, including BCR-ABL1- and ETV6-RUNX-positive acute lymphoblastic leukemia (ALL). 29423065 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE To our knowledge, this is the first successful use of nilotinib in BCR-ABL1-like phenotype ALL. 30121665 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE To address this, we studied 142 adults with ALL treated with hyperCVAD over a 10-year period who had MRD assessed by either multi-parameter flow cytometry or (for patients with Philadelphia chromosome positive ALL) reverse transcriptase polymerase chain reaction for the BCR-ABL1 translocation. 29318644 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE The breakpoint cluster region-ABL proto-oncogene 1 (<i>BCR-ABL</i>) rearrangement leads to a p210 chimeric protein in typical chronic myeloid leukemia (CML), whereas 17-25% of patients with acute lymphocytic leukemia and 0.9-3% patients with <i>de novo</i> acute myeloid leukemia (AML) carry a p190<sup>BCR-ABL</sup> fusion protein. 29151902 2017