Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE The incorporation of L-asparaginase and pegylated asparaginase into pediatric-inspired regimens has conferred a survival advantage in treatment of adults with acute lymphoblastic leukemia. 30917738 2020
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE L-asparaginase (L-Asp)-associated thromboembolisms are serious complications in pediatrics patients with acute lymphoblastic leukemia (ALL), especially at ≥10.0 years old, but the pathogenesis remains to be clarified. 31556233 2020
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE OS tends to improve with PI protocols that include L-asparaginase in AYA ALL, suggesting that therapy protocol is critical in the treatment performance of this group. 31612474 2020
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 AlteredExpression disease BEFREE Acute lymphoblastic leukemia (ALL) cells are sensitive to asparagine depletion, and administration of the asparagine depletion enzyme l-asparaginase is an important therapy option. 31659118 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE Most patients had secondary causes such as uncontrolled diabetes mellitus (30%), L-asparaginase and high-dose corticosteroid therapy for acute lymphoblastic leukemia (28%), and sirolimus/tacrolimus therapy after solid organ transplantation (14%). 29454679 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE Due to this mechanism of action observed, L-asparaginase is widely used in the treatment of Acute Lymphoblastic Leukemia, since these cells use asparagine for their survival. 30762133 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE L-asparaginase (ASNase) serves as an effective drug for adolescent acute lymphoblastic leukemia. 31523835 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE l-Asparaginase (ASNase) is an amidohydrolase used as a chemotherapeutic agent for the treatment of acute lymphoblastic leukemia (ALL). 30813054 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE Crisantaspase is an asparaginase enzyme produced by Erwinia chrysanthemi and used to treat acute lymphoblastic leukemia (ALL) in case of hypersensitivity to Escherichia coli l-asparaginase (ASNase). 30597637 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE Moreover, HAP1 levels inversely correlate with the sensitivity of the ALL cells to L-asparaginase. 31491643 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE l-asparaginase (ASNase) is a metabolism-targeted anti-neoplastic agent used to treat acute lymphoblastic leukemia (ALL). 30634463 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE L-asparaginase is a critical part of the treatment of acute lymphoblastic leukaemia in children and adolescents, and has contributed to the improvement in patient outcomes over the last 40 years. 31552479 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE Fibrinogen, von Willebrand factor antigen (VWF:Ag), total protein, and albumin levels as well as antithrombin (AT) and L-asparaginase activities were measured in 97 children with ALL treated for prolonged period of time with L-asparaginase. 30938058 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE Pegaspargase (Oncaspar<sup>®</sup>), a pegylated form of native Escherichia coli-derived L-asparaginase (hereafter referred as E. coliL-asparaginase), is indicated in the USA and EU for the treatment of acute lymphoblastic leukaemia (ALL) as a component of multi-agent chemotherapy in paediatric and adult patients. 31030380 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE L-asparaginase is an enzyme produced by microorganisms, plants, and animals, which is used clinically for the treatment for acute lymphoblastic leukemia (ALL) and, in the food industry, to control acrylamide formation in baked foods. 31104099 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE The aim of the study was to determine the level of IgM, IgG and IgE-class anti-L-asp antibodies during the induction and reinduction phases of acute lymphoblastic leukemia therapy and their influence on L-asp activity. 30826572 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE L-asparaginase is an important therapeutic enzyme used for treating ALL. 31516343 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia. 30689137 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE Experience with generic pegylated L-asparaginase in children with acute lymphoblastic leukemia and monitoring of serum asparaginase activity. 30488741 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE However, patients often relapse because of the development of resistance, but the underlying mechanism of ALL cell resistance to l-asparaginase remains unknown. 30819925 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE L-asparaginase (ASNase) from Escherichia coli is currently used in some countries in its PEGylated form (ONCASPAR, pegaspargase) to treat acute lymphoblastic leukemia (ALL). 30753228 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 GeneticVariation disease BEFREE Lipemic alterations are commonly seen in pediatric patients with acute lymphoblastic leukemia (ALL) treated with corticosteroids and L-asparaginase. 30055974 2019
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE The drug l-asparaginase is a cornerstone in the treatment of acute lymphoblastic leukemia (ALL). 29550241 2018
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE In this retrospective analysis, short-acting L-asparaginase (L-ASP) and long-acting polyethylene glycol (PEG)-asparaginase (PEG-ASP) were compared for grade 3-4 toxicities and characterized by patient and drug-related factors to identify strategies for toxicity avoidance in adults with ALL. 28355969 2018
Entrez Id: 80150
Gene Symbol: ASRGL1
ASRGL1
0.100 Biomarker disease BEFREE The soil metagenome derived L-asparaginase with enhanced activities could be a potential candidate to develop as a drug in Acute Lymphoblastic Leukemia (ALL) therapy. 29127643 2018