| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | AlteredExpression | disease | BEFREE | We conclude that abnormal MTRR mRNA expression and the methylation of the MTRR promoter can be used to classify the risk of ALL in children. | 31002356 | 2019 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | However, the results of stratified analyses revealed that MTRR A66G GG genotype was associated with decreased leukemia risk in the Caucasian population, in children and for acute lymphoblastic leukemia (ALL). | 24261678 | 2014 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | The GG genotype of the rs3776455 SNP in the MTRR gene was associated with a significantly reduced risk to ALL (p = 1.21×10(-3); OR = 0.55), which resulted mainly from the reduced risk to B-cell and hyperdiploid-ALL. | 23940529 | 2013 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | The increase in risk of adult ALL with the RFC1 80AA associated with the MTRR 66GG variant was even more significant (OR = 8.92; 95% CI 1.97-40.42). | 21657963 | 2011 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | The MTHFR 677C>T SNP and the MTRR 66A >G SNP were identified as determinants of impaired BMD(TB) in childhood ALL patients. | 20955826 | 2011 | ||||
|
0.370 | Biomarker | disease | BEFREE | We analysed common genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR), thymidylate synthase (TS), methionine synthase (MS) and methionine synthase reductase (MTRR) in 68 children with ALL and 258 healthy controls to investigate their influence on the risk for ALL. | 17454638 | 2007 | ||||
|
0.370 | Biomarker | disease | CTD_human | Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study. | 17136115 | 2007 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | In conclusion, polymorphisms in the folate-related genes MTHFR, MTRR, and SHMT1 are related to MTX resistance in pediatric patients with ALL. | 15797993 | 2005 |