| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | disease | BEFREE | The formation of a somatic mutation in the HLA-B gene throughout the development of the disease from severe aplastic anaemia to acute myeloid leukaemia. | 31733047 | 2019 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Second, we aimed to define the potential impact of HLA-B -21 variation on the course of AML in a phase 4 trial in which patients received IL-2-based immunotherapy. | 30647027 | 2019 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | HLA-B gene somatic insertion/deletion mutations in patients with acute myelogenous leukaemia. | 30051604 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | Patients and Methods By using an algorithm that was based on polymorphism-driven expression levels and specificities, we predicted and tested inhibitory and cytotoxic NK potential on the basis of KIR3DL1/HLA-B subtype combinations in vitro and evaluated their impact in 1,328 patients with AML who underwent HCT from 9/10 or 10/10 HLA-matched unrelated donors. | 28520526 | 2017 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Somatic mutation in the HLA-B gene of a patient with acute myelogenous leukaemia. | 27297335 | 2016 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Also, the HLA-A*23, HLA-A*68, HLA-B*13, HLA-B*40, and HLA-DRB1*01 alleles have been found to be negatively associated with AML. | 26199258 | 2015 | ||||
|
0.090 | Biomarker | disease | BEFREE | These results might suggest opposing effects of the HLA-B*40 in the genetic susceptibility to develop ALL or AML and offer the possibility to study further the molecular mechanisms of cell differentiation within the bone marrow lineage. | 24364037 | 2013 | ||||
|
0.090 | Biomarker | disease | BEFREE | HLA-A and HLA-B antigens in acute leukemia: A2--B12 phenotypes correlate with longer survival in acute myelogenous leukemia. | 6785965 | 1981 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | These results indicate that a gene or genes in the HLA-B region of the major histocompatibility complex can influence susceptibility to AML and also the response to chemotherapy. | 291140 | 1979 |