| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | The role of miRNA-126 in AML makes it a potential therapeutic target for successful clinical outcome. | 29940130 | 2018 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | In accordance with our observation that increased expression of miR-126 is associated with unfavorable survival in patients with t(8;21) acute myeloid leukemia (AML), we show that miR-126 overexpression exhibits a stronger effect on long-term survival and progression of AML1-ETO9a-mediated leukemia stem cells/leukemia initiating cells (LSCs/LICs) in mice than does miR-126 knockout. | 26361793 | 2015 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The results of the present study demonstrated that higher expression levels of miR-126-5p/3p in patients with AML resulted in a poorer prognosis. | 25759982 | 2015 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Our findings suggest that by targeting a single miR, that is, miR-126, it is possible to interfere with LSC activity, thereby opening potentially novel therapeutic approaches to treat AML patients. | 26055302 | 2015 | ||||
|
0.070 | Biomarker | disease | BEFREE | Our results define miR-126 as a therapeutic focus to specifically eradicate LSCs and improve AML outcome. | 24477595 | 2014 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Pediatric samples with core-binding factor AML and promyelocytic leukemia could be distinguished from each other and from MLL-rearranged AML subtypes by differentially expressed miRNAs including miR-126, -146a, -181a/b, -100, and miR-125b. | 23418555 | 2013 | ||||
|
0.070 | Biomarker | disease | BEFREE | In a large-scale miRNA expression profiling analysis of 435 human miRNAs in 52 acute myeloid leukemia (AML) samples, we found that miR-126 and its minor counterpart in biogenesis, namely, miR-126*, were specifically aberrantly overexpressed in core binding factor (CBF) AMLs including both t(8;21)/AML1-ETO and inv(16)/CBFB-MYH11 samples. | 20931398 | 2011 |