Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4301
Gene Symbol: AFDN
AFDN 		0.010 Biomarker disease BEFREE MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia. 24695851 2014
Entrez Id: 619554
Gene Symbol: MIR486-1
MIR486-1 		0.010 Biomarker disease BEFREE MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome. 25533034 2015
Entrez Id: 54790
Gene Symbol: TET2
TET2 		0.010 Biomarker disease BEFREE TET2 enzymatically converts 5-methylcytosine to 5-hydroxymethylcytosine as well as other covalently modified cytosines and its mutations are common in myeloid leukemia. 25972343 2015
Entrez Id: 406931
Gene Symbol: MIR139
MIR139 		0.010 Biomarker disease BEFREE miR-139-5p controls translation in myeloid leukemia through EIF4G2. 26165837 2016
Entrez Id: 7299
Gene Symbol: TYR
TYR 		0.010 Biomarker disease BEFREE ATN-224 may be beneficial for myeloid leukemia therapy. 26241492 2015
Entrez Id: 124540
Gene Symbol: MSI2
MSI2 		0.030 Biomarker disease BEFREE Musashi 2 (MSI2), a RNA-binding protein, was proposed to be a potent oncogene playing key roles in myeloid leukemia and gastrointestinal malignancies. 27721018 2017
Entrez Id: 7543
Gene Symbol: ZFX
ZFX 		0.010 Biomarker disease BEFREE Zinc finger protein X-linked (ZFX) is a key regulator of both embryonic stem cells (ESCs) and hematopoietic stem cells (HSCs), which is required for both Notch intracellular domain (NotchIC)-induced acute T-cell leukemia and MLL-AF9-induced myeloid leukemia in mouse models. 27797721 2016
Entrez Id: 943
Gene Symbol: TNFRSF8
TNFRSF8 		0.020 AlteredExpression disease BEFREE CD30 Expression Is Rare in Myeloid Leukemia Cutis: A Study of 55 Cases and Implications for Routine Diagnostic Algorithms. 27893466 2017
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1 		0.100 GeneticVariation disease BEFREE RUNX1 deficiency (familial platelet disorder with predisposition to myeloid leukemia, FPDMM). 28637620 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.010 Biomarker disease BEFREE IL-10-Engineered Human CD4<sup>+</sup> Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism. 28807569 2017
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1 		0.100 GeneticVariation disease BEFREE RUNX1 translocations result in the development of myeloid leukemias. 28926105 2018
Entrez Id: 4602
Gene Symbol: MYB
MYB 		0.020 Biomarker disease BEFREE MYB-driven transcriptional coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and myeloid leukemias, including refractory MLL-rearranged leukemias. 29317678 2018
Entrez Id: 2146
Gene Symbol: EZH2
EZH2 		0.010 Biomarker disease BEFREE Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors. 29438697 2018
Entrez Id: 23326
Gene Symbol: USP22
USP22 		0.010 Biomarker disease BEFREE USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism. 29844011 2018
Entrez Id: 406935
Gene Symbol: MIR143
MIR143 		0.010 Biomarker disease BEFREE MiR-143 regulates proliferation and apoptosis of myelocytic leukemia cell HL-60 via modulating ERK1. 29917183 2018
Entrez Id: 57447
Gene Symbol: NDRG2
NDRG2 		0.010 Biomarker disease BEFREE NDRG2 Sensitizes Myeloid Leukemia to Arsenic Trioxide via GSK3β-NDRG2-PP2A Complex Formation. 31121982 2019
Entrez Id: 4211
Gene Symbol: MEIS1
MEIS1 		0.050 GeneticVariation disease BEFREE Meis1 locus was isolated as a common site of viral integration involved in myeloid leukemia in BXH-2 mice. 9049632 1997
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1 		0.100 Biomarker disease BEFREE MTG8 is a counterpart gene of AML1 in acute myeloid leukemia with t(8:21) translocation. 9209371 1997
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1 		0.100 Biomarker disease BEFREE AML1, a gene on chromosome 21 encoding a transcription factor, is disrupted in the (8;21)(q22;q22) and (3;21)(q26;q22) chromosomal translocations associated with myelogenous leukemias; as a result, chimeric proteins AML1/ETO(MTG8) and AML1/Evi-1 are generated, respectively. 9473235 1998
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1 		0.100 Biomarker disease BEFREE CBFA2 forms a fusion gene with ETO and MDS1/EVI1 in translocations in myeloid leukemia and with ETV6(TEL) in the t(12;21) common in childhood pre-B acute lymphoblastic leukemia. 9763573 1998
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.080 GeneticVariation disease BEFREE D324N single-nucleotide polymorphism in the FLT3 gene is associated with higher risk of myeloid leukemias. 16320249 2006
Entrez Id: 28951
Gene Symbol: TRIB2
TRIB2 		0.020 Biomarker disease BEFREE A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. 29670085 2018
Entrez Id: 84106
Gene Symbol: PRAM1
PRAM1 		0.020 AlteredExpression disease BEFREE A case of acute eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression and response to all-trans retinoic acid. 9096703 1997
Entrez Id: 8928
Gene Symbol: FOXH1
FOXH1 		0.010 Biomarker disease BEFREE A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1. 31068365 2019
Entrez Id: 3492
Gene Symbol: IGH
IGH 		0.010 GeneticVariation disease BEFREE A greater incidence of complex translocations in myeloid leukemias than in lymphomas and lymphoid leukemias associated with IGH rearrangement. 8616794 1996