Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 GeneticVariation disease BEFREE Acute myeloid leukemia with t(8;21)(q22;q22.1)/RUNX1-RUNX1T1 and KIT Exon 8 mutation is associated with characteristic mastocytosis and dismal outcomes. 31004601 2019
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 GeneticVariation disease BEFREE The t(15;17) which generates PML-RARα, t(8;21) that produces AML1-ETO, and t(9;22) which generates BCR-ABL are the three most frequently seen chromosomal translocations in myeloid leukemia. 22714999 2012
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 Biomarker disease BEFREE This activating (or derepressing) effect of AML1/ETO may contribute to its oncogenic potential in myeloid leukemia. 18332109 2008
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 Biomarker disease BEFREE Thus, the function of PU.1 is down-regulated by AML1-ETO in t(8;21) myeloid leukemia, whereas overexpression of PU.1 restores normal differentiation. 12393465 2003
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 Biomarker disease BEFREE Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity. 11869944 2002
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 Biomarker disease BEFREE Our results provide direct evidence that AML1-ETO is critical for causing myeloid leukemia, but one or more additional mutations are required for leukemogenesis. 11526243 2001
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 Biomarker disease BEFREE AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. 11283671 2001
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 Biomarker disease BEFREE MTG8 is a counterpart gene of AML1 in acute myeloid leukemia with t(8:21) translocation. 9209371 1997
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 Biomarker disease BEFREE This translocation results in the fusion of TEL, a recently described ETS-like gene on 12p13, and AML1, which was shown to be involved in the formation of fusion genes with ETO and EVI1 in myeloid leukemias. 9498702 1997
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1
0.100 AlteredExpression disease BEFREE In vitro catalytic activities of DNA/RNA chimeric hammerhead ribozymes against AML1-MTG8 mRNA, a fused gene transcript in acute myeloid leukemia with t(8;21). 9150886 1996