Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 Biomarker disease BEFREE Previously, we observed that transcription factor RUNX1 mutations (RUNX1-MT) coexisted with ASXL1-MT in CMML and at myeloid blast phase of chronic myeloid leukemia. 31640815 2019
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 Biomarker disease BEFREE In addition, the adverse prognostic impact of ASXL1<sup>MT</sup> was partially mitigated by concurrent TET2<sup>MT</sup>, with the ASXL1<sup>WT</sup>/TET2<sup>MT</sup> genotype having better outcomes and resulting in further risk stratification of ASXL1 inclusive CMML prognostic models, in comparison to ASXL1<sup>MT</sup> alone. 31836856 2019
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 Biomarker disease BEFREE During the median follow-up of 14 months (range, 0-111 months), the overall survival (OS) of ASXL1CMML patients was significantly inferior to that of ASXL1CMML patients with a median survival of 11 months and 19 months, respectively (log-rank P=0.049). 30027691 2018
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 Biomarker disease BEFREE MP-CMML patients had significantly shorter overall survival (OS; <i>P</i> < .0001; hazard ratio: 0.53, 95% confidence interval: 0.42-0.65) and median duration to acute myeloid leukemia (AML) transformation (<i>P</i> < .0001; 15.2 vs 22.0 months) compared with MDS-CMML patients. 30054307 2018
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE This has resulted in the development of contemporary, molecularly integrated (inclusive of ASXL1 mutations) CMML prognostic models, including Molecular Mayo Model and the Groupe Français des Myélodysplasies model. 26849014 2016
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE Prognostic interaction between ASXL1 and TET2 mutations in chronic myelomonocytic leukemia. 26771811 2016
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE Therefore, a meta-analysis to study the impact of ASXL1 mutations on patients with MDS and CMML is useful. 27077763 2016
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE Exome sequencing studies in chronic myelomonocytic leukemia (CMML) illustrate a mutational landscape characterized by few somatic mutations involving a subset of recurrent gene mutations in ASXL1, SRSF2, and TET2, each approaching 40% in incidence. 27707735 2016
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE Contemporary molecularly integrated CMML-specific prognostic models include the Groupe Francais des Myelodysplasies (GFM) model and the Molecular Mayo Model, both incorporating ASXL1 mutational status. 26122388 2015
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE The study also suggests pathogenetic roles for SETBP1 and ASXL1 mutations in disease evolution into blast phase disease and CMML, respectively. 25850813 2015
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE Here, we review recent biologic observations that support the current CMML WHO classification, such as the high frequency of SRSF2 and ASXL1 mutations compared with MDS and critical dependence of CMML cells on granulocyte-macrophage colony-stimulating factor signaling. 25575034 2015
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE The current study confirms the independent prognostic value of nonsense/frameshift ASXL1 mutations in CMML and signifies its added value to the Mayo prognostic model, as had been shown previously in the French consortium model. 24695057 2014
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE Somatic, heterozygous ASXL1 mutations were identified in 14/48 (29%) of patients with GATA2 deficiency, including four out of five patients who developed a proliferative chronic myelomonocytic leukemia. 24077845 2014
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE We screened 45 patients with chronic myelomonocytic leukemia (n = 39 patients, including seven with transformed-acute myeloid leukemia), MDS/MPN unclassifiable (n = 5), and atypical BCR-ABL1-negative CML (n = 1) for mutations in ASXL1, CBL, NRAS, and TET2 genes by molecular genetics including a sensitive next-generation sequencing (NGS) technique. 24164563 2014
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 Biomarker disease BEFREE Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomes. 23531518 2013
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE In particular, ASXL1 mutations are common in patients with hematologic malignancies associated with myelodysplasia, including myelodysplastic syndromes (MDSs), and chronic myelomonocytic leukemia. 24216483 2013
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE SRSF2 and U2AF1 along with TET2 (48%) and ASXL1 (38%) are frequently affected by somatic mutations in chronic myelomonocytic leukemia, quite distinctly from the profile seen in juvenile myelomonocytic leukemia. 22773603 2013
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 AlteredExpression disease BEFREE We genotyped ASXL1 and up to 18 other genes including epigenetic (TET2, EZH2, IDH1, IDH2, DNMT3A), splicing (SF3B1, SRSF2, ZRSF2, U2AF1), transcription (RUNX1, NPM1, TP53), and signaling (NRAS, KRAS, CBL, JAK2, FLT3) regulators in 312 patients with CMML. 23690417 2013
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). 22436456 2012
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 Biomarker disease BEFREE Human ASXL1 is mutated frequently in chronic myelomonocytic leukemia (CMML) so an ASXL/BAP1 complex may suppress CMML. 22878500 2012
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE Mutations of ASXL1 correlated with an evolution toward an acutely transformed state: all CMMLs that progressed to acute phase were mutated and none of the unmutated patients had evolved to acute leukaemia. 20880116 2010
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 GeneticVariation disease BEFREE Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. 19388938 2009
Entrez Id: 171023
Gene Symbol: ASXL1
ASXL1
0.200 Biomarker disease HPO