Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 GeneticVariation disease BEFREE The National Comprehensive Cancer Network (NCCN) defines the following types of acute myeloid leukemia (AML) as favorable-risk: acute promyelocytic leukemia with t(15;17) (APL); AML with core-binding factor (CBF) rearrangements, including t(8;21) and inv(16) or t(16;16) without mutations in KIT (CBF-KIT<sup>wt</sup>); and AML with normal cytogenetics and mutations in NPM1 (NPM1<sup>mut</sup>); or biallelic mutations in CEBPA (CEBPA<sup>mut/mut</sup>), without FLT3-ITD. 29310020 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 Biomarker disease BEFREE We present a case of an 18-year-old female who was diagnosed with AML (FLT3 (Fms like tyrosine kinase 3) and PML-RARA (promyelocytic leukemia-retinoic acid receptor alpha) translocation-negative) and after initial treatment with a standard induction regimen of cytarabine and daunorubicin (3+7 regimen), her bone marrow showed blast cells less than 5% and dense aggregates/sheets of atypical/immature mast cells with immunohistochemical stain CD117+ve and toluidine blue positive in mast cell aggregates. 30800544 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 GeneticVariation disease BEFREE The weighed discriminant function reveals seven differentially expressed variables (CD2/CD9/CD11b/CD13/CD34/HLA-DR/CD117), which predict a molecular result for APL characterization with an accuracy that approaches 99% (99.6 and 98.8% for AML samples in training and test sets, respectively). 26759321 2016
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 Biomarker disease CTD_human Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide. 26285909 2015
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 Biomarker disease BEFREE In vivo Pho-s exhibits anti-proliferative effects in APL model reducing the number of CD117(+) and Gr-1(+) immature myeloid cells in the BM, spleen and liver. 24201752 2013
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 Biomarker disease BEFREE Effects of the AML-M3-associated PML/RARalpha and the AML-1/ETO as a model for CBF-AML on c-Kit signaling were investigated in trans-activation assays on the Kit promoter. 19424569 2009
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 GeneticVariation disease BEFREE We evaluated the incidence of KIT mutation in 52 adult patients with de novo CBFL and in 49 FLT3/ITD-negative childhood patients with de novo acute myeloid leukemia (AML), excluding cases of acute promyelocytic leukemia. 15339674 2004
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 AlteredExpression disease BEFREE Specifically, the promyelocytic population showed partial positivity for antigens not usually expressed in APL (HLA-DR and CD117). 12885460 2003
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 Biomarker disease BEFREE CD117 was positive in 24 (77%) of the APL cases and in none of the acute agranulocytosis cases. 12109853 2002
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.390 Biomarker disease BEFREE This report describes a unique case of acute promyelocytic leukemia (APL) showing elusive morphologic features, an atypical pattern of cytochemical reactions, and a previously unreported immunophenotype consistent with a very early myeloid form: CD13 (+), CD33 (+), CD9 (+), CD2 (+), HLA-DR (-), CD34 (+), CD117 (+), and TdT (+). 9279368 1997